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By physician referral or invitation only

Prospective Investigation of Biomarkers in HPV+ Oropharyngeal Squamous Cell Carcinoma

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Contact the Team


Thank you for your interest, but this study is recruiting by invitation only.

North Carolina

Additional Study Information

Principal Investigator

Wendell Yarbrough
Radiation Oncology - Chapel Hill

Study Type

Clinical or Medical

Study Topics

Cancer (Head and Neck)

IRB Number


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