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Groundbreaking COVID-19 Research

The UNC Institute for Global Health and Infectious Diseases is a global leader in infectious disease research and clinical care. When the pandemic began, their research teams jumped into action to fight COVID-19 head-on with exploratory treatments and new research to help both healthcare workers on the front lines and the community at large. Explore their studies and other COVID-19 research at UNC below!

COVID-19 Prevention and Vaccine Research

Researchers are looking for healthy people at high risk for COVID-19 to join the Coronavirus Prevention Network (CoVPN). CoVPN is a national registry to connect people who are interested in participating in coronavirus prevention studies with clinical research sites around the country. As clinical trials begin at UNC, or a site near you, researchers will be able to reach out to you directly to tell you about these opportunities. 

Use code "CHNC07" to volunteer for the UNC site.

Participating in COVID-19 Research

Hear from Dr. Ronald Falk, the chair of the Department of Medicine, about what it's like to participate in a COVID-19 vaccine trial. 

Dr. Cindy Gay, the principal investigator for the UNC site of the Moderna vaccine clinical trial, also explains how participants are able to help researchers solve big problems!

Explore studies you can join now!

COVID-19 Treatment Studies

Ridgeback Study

The Ridgeback clinical research study will explore whether a new anti-viral medication, EIDD-2801, given to people 18 years old and over who test positive for COVID-19 can reduce the amount of infectious virus in someone’s body. We are looking at whether this medication will reduce the spread of the virus among people, as well as potentially reduce some of the side effects of COVID-19.

    • Tested positive for COVID-19 within the past 4 days
    • Experiencing at least one symptom associated with COVID-19
    • No prior or current hospitalization associated with COVID-19
    • You have a 50/50 chance of receiving study medication OR placebo
    • Take study medications or placebo for up to 5 days
    • 3 in-home visits by study staff
    • 3 visits at UNC research clinic
    • The study will last approximately 1 month
    • Compensation – $100 per study visit
  • 919-966-6712 | This email address is being protected from spambots. You need JavaScript enabled to view it.

    or view the Research for Me listing.

ACTIV-2 Study

The purpose of this study is to evaluate the ability of various drugs to improve health outcomes for people with COVID-19. We also want to see if these drugs are safe, and if these drugs can stop the disease process and prevent hospitalization. This study is designed to quickly identify safe and effective drugs that can treat COVID-19.

  • Adults 18 years and older who:

    • Tested positive for COVID-19 less than 7 days ago
    • Have COVID-19 symptoms
    • Are at home (not in the hospital)
  • The study lasts about 6 months. You will have in person visits to check on the status of your health. Most of these visits will happen during the first month of the study. You will also have phone calls or video chats from your home with a researcher.

    Read more about this study at UNC.

  • If you think you may qualify for this study, call (877) 345-8813

    Visit https://www.activ-2.org for more information.

Regeneron Antibody Study for Household Members of Individuals Diagnosed with COVID-19

This research study is looking at experimental drugs to prevent the COVID-19 disease from occurring in people who have been exposed to the SARS-CoV-2 virus. The study drugs target the virus that causes COVID-19 and are designed to make it harder for the virus to infect you. The goals of
the study include seeing whether the study drugs lower infection by the virus, whether they reduce the need for medical visits and the amount of time you spend away from your day-to-day activities (i.e., work, school, caring for others) due to COVID-19, and whether they can cause side effects.  

    • You are 18 years or older
    • You live in the same household as someone who has been diagnosed with COVID-19.
    • Weekly visits for 1 month
    • Monthly visits for an additional 6 months
    • Participants may receive up to $1150 for taking part in this study 
    • If traveling greater than 50 miles one-way per visit, please ask the study team about reimbursement options. 
  • If you think you may qualify for this study, call 336-212-2927.

    UNC IRB #20-2355

Studies to learn more about COVID-19

OBS-C Study

The OBS-C study is an observational study that is enrolling participants that test positive AND negative to COVID-19. This study is analyzing multiple aspects of COVID-19 in people that TEST POSITIVE, including but not limited to the epidemiology and risk factors associated with SARS-CoV-2 infection, how the disease affects someone’s immune system, and the various symptoms and ways the illness is displayed in the body. The study would also like to enroll a few people that TEST NEGATIVE, but have symptoms of a respiratory illness, in order to determine the reliability of the test.

  • For Those who TEST POSITIVE:

    • 5 in-person visits at the Respiratory Diagnostic Center at UNC Chapel Hill: 4 visits, once a week, for a month, as well as a 6-month follow-up visit
    • Questionnaires & surveys administered via telephone
      Sample collection (i.e. blood draw, nasal swabs, etc.)

    For Those who TEST NEGATIVE, but have symptoms of respiratory illness:

    • Telephone visit to enroll in the study
    • One in-person visit at the Respiratory Diagnostic Center at UNC Chapel Hill approx. one month after initial telephone call
    • In-person visit will include a blood draw
  • Erin Hoffman - Coordinator

    540-290-5081 | This email address is being protected from spambots. You need JavaScript enabled to view it.

CO-HOST Study

The purpose of this research study is to understand how often COVID-19 spreads in the household when someone who tests positive for the virus self-isolates at home. Participants will have home visits conducted, as well as access to medical advice if they develop symptoms.

  • For Those who TEST POSITIVE for COVID-19:

    • 18 years and older
    • Willingness to self-isolate at home for a 14-day period
    • Living with at least one other person who is willing to participate in the study
    • Live within about 1 hour of UNC Chapel Hill

    For Those who live with someone who has TESTED POSITIVE for COVID-19:

    • Greater than 1 year old
    • Live in the same household as someone who has recently tested positive for COVID-19
    • Planning to continue living in the same household for at least the next month
    • 5 study visits over about a month
    • First 4 study visits are conducted at your house
    • Final visit will be conducted at UNC Chapel Hill
    • Participants will be asked to complete an online diary every day for 3 weeks to report any symptoms
    • Participants will receive a $50 gift card at the final visit for completion of the study
  • Christopher Basham & Maureen Whittelsey - Coordinators

    919-280-7012 | This email address is being protected from spambots. You need JavaScript enabled to view it.

COVID-19 in Farming and Food processing industries in North Carolina (COFF-NC)

The purpose of this study is to learn more about how COVID-19 spreads among people working in the food processing industry and their household members. This sample collection and questionnaire study will look at the coronavirus infection and explore new ways to prevent transmission.

    • For those who work in MEAT PACKING/FARMING/FOOD PROCESSING:
      • At least 18 years old
      • Worked in an industry above in North Carolina for at least 4 weeks since February 2020
      • Willing to give at least 1 blood sample
    • For HOUSEHOLD MEMBERS of workers:
      • At least 1 year old
      • Have a household member who works in meat packing/farming/food processing and is taking part in the study
      • Willing to give at least 1 blood sample
    • Up to 3 monthly study visits
    • Visits take place at an office in Siler City or at your home
    • Participants fill out a questionnaire and give samples (blood, nasal swab, and saliva)
    • Participants receive $25 for each study visit
  • Melissa Klein - Coordinator (habla español)

    (919) 869-5595 | This email address is being protected from spambots. You need JavaScript enabled to view it.

    or view the Research for Me listing

We have even more COVID-19 research at UNC! Some of the studies listed are recruiting by physician referral or invitation only, meaning that they are looking for very specific participants. We encourage you to explore what UNC is doing to combat COVID-19, but you won't be able to express interest in some of these studies. 

COVID-19 News & Resources

We are learning new things every day about COVID-19. For information about UNC Health's response, visit the UNC Health COVID-19 Resources page. To read stories about how UNC-Chapel Hill researchers are fighting coronavirus, visit UNC Research's COVID-19 Coverage page, and for up-to-date information and statistics about COVID-19, visit CDC.gov. 

How can you help?

Donate Plasma

Have you been diagnosed with COVID-19, tested positive for COVID-19 antibodies, or had a known COVID-19 exposure? You may be able to help patients who are currently hospitalized with COVID-19. You may be eligible to donate plasma. The UNC Blood Donation Center in Chapel Hill, NC is collecting plasma from eligible donors. Click here to learn more or This email address is being protected from spambots. You need JavaScript enabled to view it..

Sew Mask Helpers & Ear Savers

Wearing a mask all day can cause pressure on healthcare workers' ears. Please consider donating your time and skill to make mask helpers for healthcare workers. Find instructions for creating mask helpers and ear savers on UNC Health's website. 

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