• Home
  • Study Details

Biomechanical Changes Following ACL Injury that Influence PTOA

The objectives of this study are to determine: 1) the time course of changes in walking movement and physical activity following anterior cruciate ligament (ACL) injury and up to 12 months after ACL reconstruction (ACLR); 2) the associations between walking movement and physical activity with knee joint health outcomes and self-reported knee function up to 12 months after ACLR. *This study is a collaboration with the UNC Sports Medicine Institute*

Age & Gender

  • 16 years ~ 35 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)


United States (Nationwide)

What will be asked of you

Participants will complete walking movement assessments, physical activity monitoring assessments, blood draws, and surveys pre-operatively and 2, 4, 6, and 12 months post-ACLR. Lower extremity muscle strength will be assessed pre-operatively and at 4, 6, and 12 months-post ACLR. MRI knee joint imaging will be collected pre-operatively and 12 months post-ACLR.


$50 per visit (Total = Up to $250)

In-person visits:
Total length of participation:
13 months

Looking for Specific Volunteers

Able to participate:

  • recently had an anterior cruciate ligament injury
  • planning on undergoing anterior cruciate ligament reconstruction
  • between the ages of 16 and 35 years old

Not eligible if:

  • no history of anterior cruciate ligament injury

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

Department of Exercise and Sports Science
Fetzer Hall (UNC-Chapel Hill)
210 South Rd, Chapel Hill, NC 27514, USA

Secondary Visit Location

Biomedical Research Imaging Center
Marsico Hall (UNC-Chapel Hill)
125 Mason Farm Rd, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Brian Pietrosimone
Exercise and Sport Science

Study Type

Clinical or Medical

Study Topics

Bones, Joints, Muscles
Injury/Injury Prevention
Wellness and Lifestyle
Surgery and post-operative healing
Women's Health
UNC Students (undergrad, grad, professional)

IRB Number


Research for Me logo

Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH.  This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.


  • This email address is being protected from spambots. You need JavaScript enabled to view it.
logo for the North Carolina Translational and Clinical Sciences Institute
logo for UNC Health
logo for UNC School of Medicine
logo for UNC Research