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EVOLVE Study: Understanding risk for depression in the pubertal transition

Girls are almost 3 times more likely to develop mood disorders after the onset of puberty relative to males. This profound gender disparity suggests a critical role of ovarian hormones (such as estrogen) in the emergence of adolescent mood disorders. The purpose of the EVOLVE study is to learn about the effect of estrogen variation and stress in promoting mood symptoms during the pubertal transition.

Age & Gender

  • 11 years ~ 14 years
  • Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)
  • Weekend hours, if needed
  • In-home visits available


North Carolina (Chatham, Durham, Orange, Wake)

What will be asked of you

Participants will collect daily urine samples and daily and weekly mood ratings for 1 month and attend 2 in-person laboratory sessions.


Up to $320

In-person visits:
Phone or online visits:
Total length of participation:
6 weeks

Looking for Healthy Volunteers

Requirements for healthy volunteers are different than for those with a specific condition. If you are interested in becoming a healthy volunteer for this study, use the below categories to determine if you are able to participate.

Able to participate:

  • Female between the ages of 11 and 14
  • Within 1 year post-menarche (first menstrual period)
  • Undergoing a healthy pubertal transition

Not eligible if:

  • You are taking any prescription medications
  • Have had your period for over 1 year

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

UNC Women's Mood Disorder Center
UNC Health - Carolina Crossing, Building B
2218 Nelson Hwy, Chapel Hill, NC 27517, USA

Additional Study Information

Principal Investigator

Elizabeth Andersen
Psychiatry - Research

Study Type

Behavioral or Social

Study Topics

Brain, Head, Nervous System
Child and Teen Health
Glands and Hormones
Healthy Volunteer or General Population
Mental and Emotional Health
Minority Health
Parents of Children
Sexual and/or Reproductive Health
Women's Health

IRB Number


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