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Improving Walking Patterns in Individuals with an ACL Reconstruction

Individuals with a history of anterior cruciate ligament (ACL) injury and have had an ACL reconstruction (ACLR) are at a greater risk for developing osteoarthritis. The greater risk for developing osteoarthritis is likely caused by too little force or physical activity applied to the knee during weightbearing tasks such as walking. To reduce this decrease in forces during walking following an ACLR, we must first develop effective treatments that can train a person to walk in a way that reduces their risk of developing osteoarthritis. The purpose of this research study is to determine the feasibility and the initial effects of a 6-week training program designed to improve walking mechanics by targeting risk factors related to osteoarthritis development. *This study is a collaboration with the UNC Sports Medicine Institute*

Age & Gender

  • 16 years ~ 35 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)
  • Weekend hours, if needed


North Carolina (Statewide)

What will be asked of you

You are being asked to be in the study because you are between the ages of 16-35 and it has been 6 to 60 months since your anterior cruciate ligament reconstruction (ACLR). You would attend 18 sessions of training over a 6-week period and will have 3 follow-up assessments at 6, 8 weeks and 6 months. If you screen into the study there would be a series of tests related to your walking biomechanics, biomarkers from a blood draw and an MRI assessment to assess your knee cartilage. MRIs will only be conducted in adult participants (ages 18 and older). Each of the training sessions would involve you walking on an instrumented treadmill while your biomechanics are assessed. The follow-up assessments would involve a series of tests related to your walking biomechanics, biomarkers from a blood draw and urine and an MRI assessment.


$310 for Completing all Sessions

In-person visits:
Total length of participation:
1 Screening Session (2hrs), 18 Training Sessions (0.5-1hr), 3 Follow ups Sessions (~3hr), 6 months from Start to End

Looking for Specific Volunteers

Able to participate:

  • Individuals with an Anterior Cruciate Ligament Reconstruction

Not eligible if:

  • Multiple ACL reconstructions

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

MOTION Science Institute
Fetzer Hall (UNC-Chapel Hill)
210 South Rd, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Brian Pietrosimone
Exercise and Sport Science

Study Type

Clinical or Medical

Study Topics

Bones, Joints, Muscles
Minority Health
Parents of Children
Wellness and Lifestyle
Women's Health
Men's Health
UNC or UNC Health employees
UNC Students (undergrad, grad, professional)

IRB Number




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