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Ozempic Study

We are doing this study to learn if a medication commonly used for weight loss and blood sugar control affects responses to nicotine. This will provide information about whether the medication might be helpful for people who smoke cigarettes. This is not a treatment study, and it is not intended for people who are actively trying to quit smoking.

Age & Gender

  • 21 years ~ 65 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)


North Carolina (Alamance, Chatham, Durham, Granville, Guilford, Orange, Person, Wake)

What will be asked of you

Participants will be asked to take the study medication (an FDA-approved medication that helps control weight and blood sugar). Participants will attend weekly medication visits (1 hr) at UNC. Study visits will include medication, clinical measurements (heart rate, blood pressure, body weight), and questionnaires. A few of the visits will also include blood draws and urine tests. In addition, participants will attend two study visits that involve cigarette smoking. These visits will last up to 4 hours. Participants will also complete brief telephone check-ins approximately 4 times.


Up to $850

In-person visits:
Phone or online visits:
Total length of participation:
3 months

Looking for Specific Volunteers

Able to participate:

  • You smoke cigarettes daily
  • You are interested in quitting smoking in the future, but not right now
  • You are willing to take the study medication weekly for 2-3 months
  • You are available to attend weekly study visits for up to 3 months

Not eligible if:

  • You are trying to quit smoking right now (or have plans to quit in the next 3 months)
  • You use drugs other than alcohol, nicotine or cannabis
  • You are being treated for diabetes
  • You have plans to move or travel outside the Triangle area in the next 3 months

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Christian Hendershot
Psychiatry - Bowles Center for Alcohol Studies

Study Type

Clinical or Medical

Study Topics

Eating, Nutrition, and Metabolism
Healthy Volunteer or General Population
Mental and Emotional Health
Substance Use (tobacco, alcohol, opioids, etc)
Wellness and Lifestyle

IRB Number


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