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Evaluating Problematic Proteinuria in Kids (EPPIK)

This study is trying to learn more about a medication called sparsentan, and how it can help the kidneys filter protein and slow the decline of kidney function. The amount of protein found in the urine (called proteinuria) is seen as a marker of kidney function. Lowering proteinuria levels is associated with better kidney health outcomes.

Age & Gender

  • 1 years ~ 17 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • In-home visits available
  • Visits can be combined with regular clinical appointments


United States (Nationwide)

What will be asked of you

Your child will take a medicine called sparsentan every day. The medicine will be in liquid form. A blood sample and a urine sample will be collected at each study visit visit. Some study visits may be conducted at your home if you do not wish to travel.


$60 for each completed visit; up to $1,020 over 2 years.

In-person visits:
Total length of participation:
2 years

Looking for Specific Volunteers

Able to participate:

  • Focal segmental glomerulosclerosis (FSGS)
  • Minimal change disease (MCD)
  • Immunoglobulin A nephropathy (IgAN)
  • Immunoglobulin A vasculitis (IgAV)
  • Alport syndrome (AS)

Not eligible if:

  • Your child does not have one of the diseases listed in the inclusion criteria section
  • Your child has received a kidney transplant
  • Your child has a documented history of heart failure

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Keisha Gibson

Study Type

Clinical or Medical

Study Topics

Kidneys and Liver
Rare Diseases

IRB Number




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