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Heartburn Study

NERD is a disease that causes occasional heartburn (called "episodic heartburn"). This is often described as a burning sensation in your chest or throat (behind your breast bone). The purpose of this study is to learn if an experimental drug (vonoprazan) can be a potential treatment for NERD.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female

Visit Availability

  • Standard business hours (M-F, 8-5)


North Carolina (Statewide)

What will be asked of you

You will be asked to answer questions about your heartburn during the study. Most in-person visits will take approximately 1 hour. At one visit, you will undergo an upper endoscopy (a test that shows your doctor the inside of your throat and stomach). You will also receive the study drug (vonoprazan or placebo) for 4 weeks. After this, you will receive the study drug for up to an additional 20 weeks. After this, you will be asked to come into the clinic for one last visit.


Information provided upon request

In-person visits:
Phone or online visits:
Total length of participation:
33 weeks

Looking for Specific Volunteers

Able to participate:

  • Episodic Heartburn, for at least 6 months

Not eligible if:

  • Have a history of erosive esophagitis (EE)
  • Current or anticipated use of PPIs or H2 Blockers
  • Functional heartburn
  • Functional dyspepsia
  • History of esophageal surgery

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

Gastrointestinal (GI) Medicine
UNC Hospitals Hillsborough Campus
460 Waterstone Dr, Hillsborough, NC 27278, USA

Additional Study Information

Principal Investigator

Nicholas Shaheen

Study Type

Clinical or Medical

Study Topics

Stomach, Digestion and Gut Health
Eating, Nutrition, and Metabolism
Healthy Volunteer or General Population

IRB Number




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