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Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

The purpose of this study is to determine if stool or blood can be used to detect colon cancers as early or earlier than colonoscopy. The researchers plan to use these samples to learn about specific proteins (also known as biomarkers) that may indicate colon polyps, colon cancer or an increased risk of developing colon cancer. In order to learn more about preventing and detecting colon and rectal cancer, we are collecting samples from subjects with colorectal cancer who have not received any treatment.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)
  • Visits can be combined with regular clinical appointments


North Carolina (Statewide)

What will be asked of you

Participants will come to a one-hour clinic visit or meet with the study staff before a scheduled colonoscopy or if applicable, before a scheduled colon surgery or treatment. Participants will answer some health history questions, have blood drawn, and be provided a stool specimen collection kit. The stool specimen collection is done at home, before participants begin their prep for the procedure. The research team will follow up approximately one year after the procedure with a phone call about any major changes in participant health or treatment.



In-person visits:
Total length of participation:
16 months

Looking for Specific Volunteers

Able to participate:

  • You have been recently diagnosed with colorectal cancer.

Not eligible if:

  • You have been diagnosed with any other type of cancer in the last 3 years.
  • If you have received any treatment (ie chemo, radiation, surgery) for your current colorectal cancer.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Contact

Secondary Visit Location

GI Clinic
REX Digestive Healthcare
2417 Atrium Dr, Raleigh, NC 27607, USA

Additional Study Information

Principal Investigator

Sarah McGill

Study Type

Clinical or Medical

Study Topics

Cancer (Colorectal)
Stomach, Digestion and Gut Health

IRB Number


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