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Goodpasture Disease (Anti-GBM) Research Study

Patients hospitalized with anti-glomerular basement membrane (anti-GBM) antibody disease, an autoimmune disease, are treated with a number of medications to stop the inflammation created by the disease. In this study, we want to see if adding the drug imlidifase to those usual treatments will stop the inflammation faster and helps reduce damage to the kidneys.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Visits can be combined with regular clinical appointments


North Carolina (Statewide)

What will be asked of you

While you are being treated in the hospital, you would be placed at random , like the flip of a coin, into one of two groups. The first group will receive regular treatment, and the second group will receive regular treatment plus an infusion of an investigational drug (imlidifase). After your hospitalization, there will be 6 follow-up visits with a physical exam, blood draw, urine collection, and questions about your health.


free study drug

In-person visits:
Total length of participation:
2 years

Looking for Specific Volunteers

Able to participate:

  • you have been diagnosed with anti-GBM antibody disease (Goodpasture disease)
  • you have low kidney function (eGFR <20 ml/min/1.73m2)

Not eligible if:

  • you are pregnant or breastfeeding
  • you have received more than 4 sessions of dialysis recently
  • you have had recent heart problems
  • you don't produce urine anymore

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Vimal Derebail

Study Type

Clinical or Medical

Study Topics

Kidneys and Liver
Lungs and Breathing

IRB Number


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