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Adolescent Mood during Puberty and Testosterone (AMPT)

Female and male adolescents may respond differently to pubertal changes in hormones including testosterone. This study will examine whether brain activity associated with emotion regulation may link testosterone change with different symptoms. Further, we will test the effects of a smartphone-based training program on brain dynamics underlying emotion regulation and symptoms of depression - the first step in developing new intervention and treatment approaches for adolescent psychopathology.

Age & Gender

  • 11 years ~ 14 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Weekend hours, if needed


North Carolina (Chatham, Durham, Orange, Wake)

What will be asked of you

This study will be a hybrid of remote and in-person sessions and will last approximately 8 weeks, with a two-month follow-up period. During this study, you will participate in an enrollment session (~1 hour), which includes a clinical interview, weekly hormone (saliva) collections and mood ratings, along with 3 cognitive-emotional processing (biobehavioral laboratory) sessions with electroencephalography (EEG). You will also complete a 4-week mobile health training program (Healthy Minds Program) administered on your personal cell phone, and 2 monthly follow-up surveys.


Up to $265 on e-giftcard

In-person visits:
Phone or online visits:
Total length of participation:
4 months

Looking for Healthy Volunteers

Requirements for healthy volunteers are different than for those with a specific condition. If you are interested in becoming a healthy volunteer for this study, use the below categories to determine if you are able to participate.

Able to participate:

  • You are between the ages of 11 and 14
  • You are undergoing a healthy pubertal transition
  • You are not taking any prescription medication that alters mood or hormones
  • You have a personal mobile device that you can install the training program (app)
  • Experiencing increased stress and mood symptoms during puberty

Not eligible if:

  • puberty seems completed

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Visit Study Website

Primary Visit Location

UNC Health - Carolina Crossing, Building B
2218 Nelson Hwy, Chapel Hill, NC 27517, USA

Additional Study Information

Principal Investigator

Elizabeth Andersen
Psychiatry - Research

Study Type

Behavioral or Social

Study Topics

Brain, Head, Nervous System
Glands and Hormones
Mental and Emotional Health

IRB Number




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