Pancreatic Cancer with Electron intraoperative Radiation therapy

We want to research how well Intraoperative Radiation therapy during surgery works in treating pancreatic cancer after 3-6 months of chemotherapy and external radiation therapy. This multi-center, phase II study will enroll patients with either borderline-resectable or locally advanced unresectable pancreatic cancer who have already received chemotherapy and radiation therapy. Patients will be stratified for analysis based on the extent of their disease at initial diagnosis. All patients will receive the same protocol-specified intervention of electron beam intraoperative radiation therapy (IORT). IORT will be administered as determined to be best practice by the study doctor. IORT will be administered in 1 day.