Individuals with a history of anterior cruciate ligament (ACL) injury and have had an ACL reconstruction (ACLR) are at a greater risk for developing osteoarthritis. The greater risk for developing osteoarthritis is likely caused by too little force or physical activity applied to the knee during weightbearing tasks such as walking. To reduce this decrease in forces during walking following an ACLR, we must first develop effective treatments that can train a person to walk in a way that reduces their risk of developing osteoarthritis. The purpose of this research study is to determine the feasibility and the initial effects of a 6-week training program designed to improve walking mechanics of individuals with an ACL reconstruction.

Have you been diagnosed with schizophrenia? Have you ever been prescribed clozapine? If you answered yes to both questions, you may be able to participate in a research study to find out how clozapine affects brain function to improve schizophrenia symptoms. Compensation provided.

Are you a healthy person? Have you wanted to get involved in clinical research in lung diseases? If so, you can join our registry list of interested individuals through a quick online form. We will give you a call if there are studies that you may be eligible for.

Do you have mantle cell lymphoma or other non-Hodgkin lymphoma that has either come back or did not get better with your last treatment? If so, you may be able to take part in a study that will modify your own immune cells to see if it may treat your cancer.

Have you been diagnosed with primary central nervous system (CNS) lymphoma? If so you may be able to take part in a research study looking at whether using the study drugs lenalidomide, and nivolumab can be safely used in addition to the standard treatment of primary CNS lymphoma, and which dose is the most adequate when they are used together.

For caregivers of grieving children who weren't the romantic partner of the parent who died (if you weren't together as a couple) at the time of their death, please help us better understand your experience. Sharing your thoughts will help us create better resources and support for families like yours.

If you are seen at UNC and have been diagnosed with monoclonal gammopathies or amyloidosis, and the disease is affecting your kidneys, we would like your permission to access your medical record to learn about your treatments and how well they work.

Have you recently had an anterior cruciate ligament re-injury and will be undergoing revision anterior cruciate ligament reconstruction surgery? If so, you may be able to participate in a study assessing the associations between walking movement and physical activity with knee joint health. Compensation provided.

The CureGN Network acts as a "library" of data for investigators across the world to use to help us ask the following questions: 1) What is the disease?; 2) Why did it happen to me?; 3) Can it be passed down to my family members?; 4) What treatments work the best with the least side effects?

Would you like to participate in research studies to help better understand lung health and the effect of air pollution on the lungs? We are currently looking for people with no history or asthma or smoking to see if you are eligible for other studies surrounding these topics.