This is a research study involving an investigational drug called RT234 (also called the study drug). The study drug is being developed to treat pulmonary arterial hypertension (PAH). The purpose of this study is to collect more information about the ability of RT234 to improve exercise capacity and safety of RT234 for the treatment of pulmonary arterial hypertension.

There is a movement toward addressing social risk factors as part of healthcare delivery, with similar efforts launched by the CF Foundation. However, current social screening tools do not capture the unique risks and needs of people with CF, have not been tailored to adults with CF vs caregivers of children with CF, and have not been adapted to multidisciplinary CF care delivery. Our work also showed <20% of those who report needs access help, and found barriers related to stigma, guilt, or fear. It is critical to develop a social screening instrument that is specific to adults and caregivers of children with CF, acceptable to them, and rigorously tested for reliability and validity. Using a community-engaged process, we will systematically address these knowledge gaps.

This is an exploratory study in cancer biomarker research, hoping to identify cell-signaling using DNA, in patients with SCLC.

Gather detailed information on the health and treatment of patients with severe asthma worldwide, track how well patients are responding to treatment, and undertake medical research using data from the registry to improve asthma treatment and care.

This study hopes to identify barriers to care for patients with interstitial lung disease by surveying patient experiences with symptoms, diagnosis, ongoing treatment of their lung disease.

In this study we will measure medical mistrust among surrogate decision makers of intensive care unit patients that are unable to make their own decisions because they are too sick. We will then monitor various outcomes using the electronic medical record to make associations between surrogate medical mistrust and patient goals of care. We suspect that more mistrustful surrogate decision makers will require more time to make end of life decisions in the intensive care unit.

We don't know whether discharging patients with active delirium (aka confusion) home is appropriate. Returning patients to their home may lead to improvement and quicker delirium resolution. Alternately, it may be harmful as delirious patients may not be able to appropriately care for themselves in the home environment or follow discharge instructions. Consequently, they may get sicker, requiring hospital readmission or worse. Currently, there is no good way to assess delirium in the home setting. This greatly limits the ability to monitor and study this vulnerable population. The ability to perform in-home delirium assessments will prove invaluable to researchers investigating the a-propriateness of discharging actively delirious patients' home versus keeping them in the hospital until resolution of their delirium. Further, it will provide a method for clinicians to perform quick, remote delirium assessments of their patients.

Assessing the ability of a sensor for inhalers to measure inhaled volume and improve inhaler technique

Hypothesis: The development of patient-focused tools and care processes will enable a transition from predominantly office-based CF care to a more convenient, co-produced model. The increased utilization of remote care will be associated with improved adherence to disease monitoring and complication screening guidelines and will increase patient satisfaction. Specific Aims: 1. Customize a patient-facing smartphone application (Nudge) designed to "coach" each patient toward a co-produced goal of convenient and effective health monitoring within the context of enhanced remote care. 2. Develop care processes that facilitate monitoring of respiratory status at home, using home spirometry and remote sputum collection, that include education, electronic reminders, and specimen collection/shipping supplies 3. Implement care processes that allow convenient access to necessary screening procedures, using the Nudge application to provide well-timed electronic reminders and track performance of screening tests.

This study is designed to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in patients with PAH.