This registry will collect data on the strategies used to achieve a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype (ILD) and the treatment and management efforts applied throughout study follow-up, clinical outcome events and patient reported outcome data. Blood samples will be collected periodically throughout the study for use in future research efforts. For participants with non-IPF, chronic fibrosing ILD with progressive phenotype, HRCT images will be collected throughout the study for use in future research efforts.

This is an exploratory study in cancer biomarker research, hoping to identify cell-signaling using DNA, in patients with SCLC.

The DNA that we can test from a nasal swab, can help us determine a patient's lung cancer risk. For patients with new lung nodules found on CT scans, we are offering this nasal swab test and collecting data on how physicians use test results to help assess risk and determine treatment strategies.

We don't know whether discharging patients with active delirium (aka confusion) home is appropriate. Returning patients to their home may lead to improvement and quicker delirium resolution. Alternately, it may be harmful as delirious patients may not be able to appropriately care for themselves in the home environment or follow discharge instructions. Consequently, they may get sicker, requiring hospital readmission or worse. Currently, there is no good way to assess delirium in the home setting. This greatly limits the ability to monitor and study this vulnerable population. The ability to perform in-home delirium assessments will prove invaluable to researchers investigating the a-propriateness of discharging actively delirious patients' home versus keeping them in the hospital until resolution of their delirium. Further, it will provide a method for clinicians to perform quick, remote delirium assessments of their patients.

Assessing the ability of a sensor for inhalers to measure inhaled volume and improve inhaler technique

Hypothesis: The development of patient-focused tools and care processes will enable a transition from predominantly office-based CF care to a more convenient, co-produced model. The increased utilization of remote care will be associated with improved adherence to disease monitoring and complication screening guidelines and will increase patient satisfaction. Specific Aims: 1. Customize a patient-facing smartphone application (Nudge) designed to "coach" each patient toward a co-produced goal of convenient and effective health monitoring within the context of enhanced remote care. 2. Develop care processes that facilitate monitoring of respiratory status at home, using home spirometry and remote sputum collection, that include education, electronic reminders, and specimen collection/shipping supplies 3. Implement care processes that allow convenient access to necessary screening procedures, using the Nudge application to provide well-timed electronic reminders and track performance of screening tests.

To collect research samples from CF patients already having a clinically indicated colonoscopy. We're collecting a few additional samples on top of what is collected for clinical purposes to give to researchers for future projects. This will increase your time of procedure around 5 minutes.

To follow people with cystic fibrosis who have cultured a positive NTM bacteria.

The primary objective of PATIENCE is to develop a standardized approach to the treatment of NTM in CF patients with a diagnosis of NTM disease. The secondary objectives are to: - Evaluate the feasibility and tolerability of a standardized treatment protocol for NTM disease - Evaluate effectiveness of a standardized NTM disease treatment protocol to serve as baseline/reference estimates of endpoints in clinical care and future therapeutic trials - Support biomarker development for markers of NTM treatment response through banking of clinical specimens and NTM isolates linked with outcomes data - Characterize clinical features of patients achieving treatment success compared to those unresponsive to treatment

This study will test how effectively changes in lung structure and function can be detected with a new inhaled gas combined with a MRI.