The purpose of this trial is to allow patients who are currently on the PROSERA trial to receive medication until the study drug is commercially available.

Gather detailed information on the health and treatment of patients with severe asthma worldwide, track how well patients are responding to treatment, and undertake medical research using data from the registry to improve asthma treatment and care.

We are looking for links between cystic fibrosis outcomes and a history of intimate partner violence.

We are performing a clinical study to determine the optimal frequency for medications for infected pleural fluid, referred to as intrapleural enzyme therapy (IET). Participants will either receive once daily IET or twice daily IET. We hypothesize that once daily IET will be non-inferior to twice daily IET.

This is an exploratory study in cancer biomarker research, hoping to identify cell-signaling using DNA, in patients with SCLC.

Hypothesis: The development of patient-focused tools and care processes will enable a transition from predominantly office-based CF care to a more convenient, co-produced model. The increased utilization of remote care will be associated with improved adherence to disease monitoring and complication screening guidelines and will increase patient satisfaction. Specific Aims: 1. Customize a patient-facing smartphone application (Nudge) designed to "coach" each patient toward a co-produced goal of convenient and effective health monitoring within the context of enhanced remote care. 2. Develop care processes that facilitate monitoring of respiratory status at home, using home spirometry and remote sputum collection, that include education, electronic reminders, and specimen collection/shipping supplies 3. Implement care processes that allow convenient access to necessary screening procedures, using the Nudge application to provide well-timed electronic reminders and track performance of screening tests.

The DNA that we can test from a nasal swab, can help us determine a patient's lung cancer risk. For patients with new lung nodules found on CT scans, we are offering this nasal swab test and collecting data on how physicians use test results to help assess risk and determine treatment strategies.

We don't know whether discharging patients with active delirium (aka confusion) home is appropriate. Returning patients to their home may lead to improvement and quicker delirium resolution. Alternately, it may be harmful as delirious patients may not be able to appropriately care for themselves in the home environment or follow discharge instructions. Consequently, they may get sicker, requiring hospital readmission or worse. Currently, there is no good way to assess delirium in the home setting. This greatly limits the ability to monitor and study this vulnerable population. The ability to perform in-home delirium assessments will prove invaluable to researchers investigating the a-propriateness of discharging actively delirious patients' home versus keeping them in the hospital until resolution of their delirium. Further, it will provide a method for clinicians to perform quick, remote delirium assessments of their patients.

Assessing the ability of a sensor for inhalers to measure inhaled volume and improve inhaler technique

This study is designed to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in patients with PAH.