The purpose of current study is to test the feasibility and repeatability of MCC measurements made with the SILP method at 6 study sites. If successful, this will provide the groundwork needed to proceed with multi center therapeutic trials using this MCC assay.

Patients will undergo a blood draw for a gene classifier test. Some patients will have their physicians informed of the result, and another group of patients will be randomized to be managed by standard of care. Qualifying patients have incidentally identified lung nodules assessed as < 50% risk of cancer.

This study will investigate whether a series of educational sessions focused on stress management (delivered by telehealth) will improve symptoms of depression and anxiety in adults with cystic fibrosis.

Assessing symptoms and disease impact of pulmonary hypertension and interstitial lung disease in patients on medication for their pulmonary hypertension to learn more about this disease & focus on patient-centered outcomes.

To see if patients benefit from IV amino acids and exercise while in the ICU.

The MAYFLOWERS study is being done to look at how pregnancy affects the health of women with cystic fibrosis (CF) and to look at the health of babies born to women with CF.