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UNC-Chapel Hill Department of Radiation Oncology

15 studies match your search
By physician referral or invitation only

Biomarker for cervical cancer screening study

To determine if plasma circulating HPV DNA (cHPVDNA) has potential as a non-invasive biomarker for identification and treatment monitoring of cervical intraepithelial neoplasia grades 2-3 by characterizing correlation between plasma cHPVDNA levels and cervical intraepithelial neoplasia grade prior to intervention and after excision.

Age & Gender
  • 18 years ~ 99 years
  • Female
Study Interest
  • Cancer (Cervical)
  • Immune System/Infections
  • Sexual and/or Reproductive Health
  • Women's Health
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Pancreatic Cancer with Electron intraoperative Radiation therapy

We want to research how well Intraoperative Radiation therapy during surgery works in treating pancreatic cancer after 3-6 months of chemotherapy and external radiation therapy. This multi-center, phase II study will enroll patients with either borderline-resectable or locally advanced unresectable pancreatic cancer who have already received chemotherapy and radiation therapy. Patients will be stratified for analysis based on the extent of their disease at initial diagnosis. All patients will receive the same protocol-specified intervention of electron beam intraoperative radiation therapy (IORT). IORT will be administered as determined to be best practice by the study doctor. IORT will be administered in 1 day.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female
Study Interest
  • Cancer (Pancreatic)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

PSMA-PET/MRI Low and Intermediate-Risk Target Volume Pilot Study

This is a pilot trial testing the safety and feasibility of using PSMA-PET and mpMRI to optimize radiotherapy targets for patients with low-risk or intermediate-risk prostate cancer.

Age & Gender
  • 18 years ~ 99 years
  • Male
Study Interest
  • Cancer (Prostate)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Using PSMA-PET/MRI for Unfavorable-Risk Prostate Cancer Patients Receiving Radiation

To determine the feasibility and toxicity of using prostate-specific membrane antigen-positron emission tomography (PSMA-PET) and multi-parametric magnetic resonance imagining (mpMRI) to guide target volumes for patients with unfavorable-risk prostate cancer receiving radiation.

Age & Gender
  • 18 years ~ 99 years
  • Male
Study Interest
  • Cancer (Prostate)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

A Prospective Comparative Study of Outcomes with Proton and Photon Radiation in Prostate Cancer

Two types of radiation treatment are routinely used for prostate cancer: photon (X-ray )therapy and proton therapy. The purpose of this study is to directly compare the two therapies to determine which one has better disease control and fewer patient-reported and physician-reported side effects.

Age & Gender
  • 18 years ~ 99 years
  • Male
Study Interest
  • Cancer (Prostate)
  • Men's Health
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients with Stage I/II Non-small Cell Lung Cancer

AstraZeneca AB is doing this research to find out if the medication called durvalumab will work and be safe for the treatment of patients with Stage I/II Non Small Cell Lung Cancer following stereotactic body radiation therapy.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Cancer (Lung)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Treatment Outcomes of UNC Patients with Head and Neck Cancer

This is a retrospective study whose goal is to record and analyze outcomes following treatment of head and neck cancers at the University of North Carolina, Chapel Hill. Studying patient characteristics, treatments and outcomes may yield information that could further improve therapy for future patients.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Cancer (Head and Neck)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Prospective Investigation of Biomarkers in HPV+ Oropharyngeal Squamous Cell Carcinoma

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Cancer (Head and Neck)
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Identifying Workplace Stressors at UNC that Lead to Burnout

Burnout within the health care setting is a known problem. The COVID-19 pandemic has lead to dramatic changes in the health care workplace and may lead to worsening burnout. This study aims to identify the most worrisome workplace stressors at UNC across departments so that changes can be made to address burnout.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Opinions and Perceptions
  • Social or Workplace Dynamics
  • COVID-19
  • and 2 more
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Feasibility of Electronic Questionnaires for Patients With Gynecologic Cancer

The goal of this study is to see if it is feasible to use electronic questionnaires to measure patient related outcomes before, during, and after radiation for gynecologic cancer in a high-volume radiation oncology clinic.

Age & Gender
  • 18 years ~ 99 years
  • Female
Study Interest
  • Cancer (Cervical, Other Cancers, Uterine (endometrial))
Visit Location
100% Remote (online, phone, text)
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