Are you a patient with locally advanced or metastatic squamous cell carcinoma? If so, you may be eligible to participate in a clinical research study involving an investigational drug, NBTXR3.

Can we increase the clinical complete response rate (tumor disappears by exam, endoscopy, and imaging) by adding a 3rd drug (irinotecan) to the standard regimen of FOLFOX or CAPOX given following long-course chemoradiation for patients with locally advanced rectal cancer? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your rectal cancer. The usual approach is defined as care most people get for locally advanced rectal cancer.

Do you have newly-diagnosed multiple myeloma? If so, you may be able to participate in a research study looking at the safety, efficacy, and tolerability of giving isatuximab in combination with lenalidomide and dexamethasone at lower doses.

Have you been diagnosed with multiple myeloma that has not responded to treatment or has come back after treatment? If so, you may be able to take part in a research study looking at the safety and efficacy of giving a new drug called ABBV-383 to patients with relapsed/refractory multiple myeloma.

The purpose of this observational study is to follow Endometrial Cancer patients through standard of care treatment of their Endometrial Cancer and collect biomedical and patient reported outcomes data.

Do you have ovarian or peritoneal cancer? if so, you may be able to participate in a research study comparing the treatment of carboplatin/paclitaxel and letrozole hormonal therapy to letrozole alone to see if the treatment can shrink or stabilize your cancer.

Have you been diagnosed with uterine pre-cancer (endometrial intraepithelial neoplasia, EIN) ? if so, you may be able to participate in a research study to see if giving metformin and megestrol acetate together may decrease the growth of endometrial intraepithelial neoplasia in the uterus better than megestrol alone.

Have you been diagnosed with uterine cancer called endometrial serous carcinoma or carcinosarcoma? If so, you may be able to take part in a research study to test if adding a drug or drugs that target HER2 proteins in addition to the usual combination of chemotherapy drugs could prevent your cancer from returning or shrink your cancer.

Have you been diagnosed with Metastatic Castration-Resistant Prostate Cancer. If so, you may be able to take part in a research study looking at the safety of giving Docetaxel vs Docetaxel and Radium-223 to patients.

Do you have known or suspected lung and/or head and neck cancer? Are you scheduled for a tumor biopsy? If so, you may be able to participate in a research registry aimed at learning more about lung and head/neck cancer.