Do you have asymptomatic multiple myeloma, also known as smoldering multiple myeloma? You may be able to take part in a research study to help us learn more about the effectiveness of a drug called daratumumab in combination with lenalidomide and steroids.

In this study, we want to compare different combinations of drugs for patients with multiple myeloma who have not responded to previous treatment. We want to learn if an investigational medication may be beneficial for the treatment of multiple myeloma.

Have you been diagnosed with multiple myeloma that has returned and needed to be treated again? If so, you may be able to take part in a research study looking at the safety of giving a new drug called REGN5458 (Linvoseltamab) to patients with relapsed/refractory multiple myeloma.

Immune checkpoint inhibitors (ICIs) are a type of cancer treatment that work by over-activating the immune system to find and kill cancer cells. This type of treatment can sometimes lead to side effects that look like autoimmune diseases (diseases where the immune system attacks the body). We want to collects samples and clinical data from cancer patients taking ICI therapy to understand why some patients get side effects and others don't.

The purpose of this research study is to deliver 6 months of 1:1 health coaching to cancer patients being treated at UNC Cancer Hospital. This program hopes to improve patient's self-confidence and satisfaction with how they feel and what they are able to do day-to-day. This includes exercising, support for healthy eating, emotional and social needs. Health coaching means you will receive weekly phone calls and emails from a trained coach.

Have you been diagnosed with multiple myeloma or high-risk smoldering multiple myeloma? If so, you may be able to take part in a research study looking at how drugs used to treat multiple myeloma work.

Have you been diagnosed with a plasma cell disorder? You may be able to join a registry to help us learn more about the effects of plasma cell disorders on different aspects of life.

Cancer caregivers experience high levels of stress related to the caregiving role, particularly for rural caregivers. The purpose of this study is to assess the acceptability and preliminary effect of enCompass Carolina, a social support program for caregivers of rural-dwelling patients with cancer.

The purpose of this study is to create a registry that will collect clinical data from participants attending UNC Hospitals who may present with metastatic cancer and are evaluated to receive radiation therapy. We hope to create a registry that future studies can pull from to study the impacts of radiation therapy on patient cancer outcomes.

The purpose of this study is to learn how having specific help over a period of time (financial navigation) can help reduce your distress related to the cost of cancer. You will complete a survey to see if you have financial distress. If you have financial distress, you will then fill out a few more surveys and be asked more details about your current financial situation to determine what programs could be helpful for you. The surveys can be completed in person, by email, or over the phone. The navigator can help you complete the surveys if needed. After that, depending on your needs, you will have 1-6 appointments with the financial navigator over a period of 2 weeks -4 months. Risks to you are small due to the educational nature of this study. They may include mild emotional distress while talking about your cancer and financial experiences. Benefits