The purpose of the registry is to better characterize physical characteristics of patients with peripheral neuropathies and generate a group of well-studied patients.

To Assess the Long-Term Safety and Efficacy of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

The goal of this study is to find out if, and how, controlling childrens' temperatures by cooling their body in the days after cardiac arrest can help the brain recover. Cardiac arrest means that the heart stopped beating. Brain injury due to a cardiac arrest may prevent a child from waking up or doing the things they were able to do before the arrest. Brain injury may cause a child to have slower development and/or loss of previous skills controlled by the brain, such as talking, feeding themselves, thinking, and walking. This study will see if cooling a child a few degrees below normal temperature, called therapeutic hypothermia, will help improve a child's chance of recovering brain function after a cardiac arrest.

We are studying the relationships between migraine and postpartum mood for the first three months after childbirth. We are interested in how women are able to cope with their migraine symptoms during the postpartum (after childbirth), and whether this affects their mood. We know that migraine and postpartum mood can be worse in women who have lower income and who identify with a minoritized racial or ethnic group. We are exploring why.

we want to learn more about seizure activity while a patient with epilepsy is not seizing or is at "rest" using data from resting state intracranial EEG (rs-iEEG) and resting state functional MRI (rs-fMRI).

The purpose of this research study is to investigate the relationship between sleep brain wave patterns and peripheral glucose (sugar) levels in individuals with and without type 2 diabetes mellitus (T2DM). Participants will undergo continuous glucose monitoring (CGM) using a CGM device for up to two weeks before an in-laboratory sleep study which is part of routine medical care at UNC to examine how sugar levels fluctuate during sleep and how these fluctuations relate to brain wave activity

The purpose of this study is to test the safety and effectiveness of DNTH103 for patients who have MMN (multifocal motor neuropathy)

To determine the safety and preliminary efficacy of focused ultrasound ablation for focal-onset epilepsy.

NEU-411 is being studied to see if it can slow Parkinson's Disease (PD) progression in individuals with PD who have LRRK2 pathway overactivity (referred to as LRRK2-driven) based on their genetic profile.

The purpose of this study is twofold: 1) to explore the association between self-reported concussion history and prevalence of self-reported lower extremity injury among lacrosse and ice hockey athletes with and without a concussion history and 2) to evaluate if sex is an effect modifier for the association between previous concussion and lower extremity injury. We will utilize an online survey including pre-validating injury history questionnaires (1,2) to conduct a descriptive epidemiological study. These data can be used to better understand the association between concussion history and lower extremity injury while considering sex as an effect modifier.