This project is studying the effect of pediatric care coordination on the behavioral health of children and parents.

Systematic reviews (SRs) of healthcare interventions should identify patient safety concerns; however, many SRs are designed to assess benefits, and preliminary evidence suggests that conclusions about harms in SRs might not be trustworthy. Using >19,000 SRs of drugs for which we have full texts (including >4,000 overlapping reviews), and using innovative methods for analysis (e.g., natural language processing), we will examine whether information about safety in SRs is consistent, whether SRs address safety concerns identified using real-world evidence, and whether SRs are consistent with safety information on drug labels. Based on best evidence, including findings from this study, we will develop contemporary guidance for synthesizing and reporting safety information in SRs.

This Incubation Project is motivated by ethical questions around policies and practices concerning research engagement with U.S. Indigenous Peoples whose tribes are unrecognized by the federal government. The pilot study includes activities aimed at (1) elucidating their perspectives on environmental research ethics, (2) evaluating the breadth and depth of current environmental research engagements within their communities, and (3) assessing their perspectives and gathering feedback on emerging research policies.

The purpose of Heroes Health is to support COVID-19 worker health.

The primary purpose of this study is to determine differences in proportions of participants achieving clinical remission at Week 12, comparing eltrekibart versus placebo, in adult patients with moderate-to-severe UC. This will be followed by a 40-week Maintenance Period to explore safety and the durability of remission.

The aim of this questionnaire is to explore awareness, perceptions and utilisations of PPI (Patient & Public Involvement) and the barriers to its use among researchers within the Psychiatric Genomics Research community. This survey is part of ongoing work from the Psychiatric Genomics Consortium (PGC) Outreach Committee and the International Society of Psychiatric Genetics (ISPG). Data will inform the PGC Outreach Committee on how it can support PGC members in their outreach activities and will be shared at a PGC World Wide Lab 2024/2025.

This study will test how effectively changes in lung structure and function can be detected with a new inhaled gas combined with a MRI.

The purpose of this research study is to survey what is currently being practiced among current third/fourth year dental students at the UNC Adams School of Dentistry with regards to treatment of dental infections.

We want to learn why and how some people on dialysis form blood clots in the dialysis machine or in their fistula. Most patients on dialysis receive a blood thinner called heparin to prevent these clots, but heparin can sometimes cause bleeding. We would like to know if safer medications could work in preventing these clots. This study is only about learning more information from blood samples and does not involve treatment.

The purpose of this study is to determine if peak flow meter data correlate well with other measures of subglottic disease severity and to see if peak flow meters can be utilized to monitor subglottic stenosis disease progression at home.