The objectives of this pivotal clinical trial are to evaluate the safety and effectiveness of the PASCAL System for transcatheter tricuspid valve repair with OMT (optimal medical therapy) compared to OMT alone in the treatment of patients with symptomatic severe tricuspid regurgitation.

You are being asked to take part in this study because you previously agreed to receive a U.S. Food and Drug Administration (FDA) approved drug, idecabtagene vicleucel (ide-cel), for the treatment of your disease as part of routine care and not a clinical research study. You had the blood collection (leukapheresis) (pronounced loo-ka-fer-ee-sis) procedure, your T cells (a subset of your white blood cells that are part of your immune system and attack things like infections and cancer cells) were collected and genetically modified in a laboratory in order to manufacture the ide-cel T cells for your disease treatment. The ide-cel T cells that were produced do not meet all of the prespecified release criteria to be used as a routine prescription drug as required by the governing health authority (such as the FDA) where you are being treated. For example, the modified T cells may have a lower cell

Purpose is to evaluate the ear tube simulator and compare to actual ear tube placement in patient.

We are studying how students respond to the information provided by grades in their courses and whether the grades they receive influence their subsequent selection of courses. We are especially interested in how this information influences students who are pursuing or thinking of pursuing a STEM major.

The purpose of this study is to help us better understand how patients with KS will respond to treatment with chemotherapy. We know from previous research studies that even though chemotherapy cannot cure KS, it can help a lot to improve symptoms caused by KS and cause KS lesions to become less or even go away for long periods of time.

Flooding is a frequent, expensive, and life-threatening hazard across the United States. Some towns have limited flooding damage by limiting the amount of new development in floodplains (areas known to be at risk of repeat flooding). This project explores why some towns have been able to limit development while others have aggressively built in the floodplains. We interview local stakeholders and residents in eight towns (four that have limited floodplain development and four that have not). We will ask about regulations that limit development and control flood risk in their towns. We will ask about why these regulations were or were not adopted, the process of adoption, how they are enforced, and any challenges faced. We will ask about their experiences with the regulations and their perceptions of flood risks. Our goal is to identify lessons learned that can help other towns improve their floodplain management.

As part of its commitment to expand access to treatment for substance use disorders (SUDs), North Carolina's Department of Health and Human Services is pursuing a Section 1115 demonstration waiver to strengthen its SUD delivery system. Part of the waiver process involved a mid-point assessment of the implementation plan and recommendations to be delivered to the NC DHHS.

The SISTER study is comparing different kinds of support for Black patients during endometrial cancer treatment. SISTER is a "randomized controlled trial", or RCT. This means that if you decide to volunteer, a computer will assign you to a group. There are three groups in the study, and you will get support no matter what group you are in. You will also complete surveys and give us permission to collect information from your medical record that is related to the study.

This is a longitudinal cohort study with a concurrent mixed-methods design to determine the interrelationship between how stroke survivors adapt to and longitudinal changes in fatigue and recovery of physical function within 6 months poststroke (during index hospitalization, 1, 3, and 6 months).

This study will be the first to investigate potential linkages between early life adversity, parenting quality, child self-regulation, and biological aging during the critical period in early childhood when telomeres are eroding most rapidly and may be most susceptible to environmental input. The long-term goal is to determine how early adversity becomes biologically embedded in early childhood in order to prevent or mitigate risk to later health and wellness. Findings will provide important information to help in the development and/or optimization of early risk-mitigating intervention and prevention efforts to improve the quality of life for children.