The purpose of this research is to improve early diagnosis of familial hypercholesterolemia (FH) and through the implementation of cascade screening, or family genetic testing for FH. To identify areas for improvement, we are recruiting stakeholders to participate in qualitative interviews. We will use this information to better understand barriers and facilitators for a specific diagnostic strategy called cascade screening. This strategy involves contacting family members to discuss their risk of having familial hypercholesterolemia and arranging for screening to check for very high cholesterol and genes associated with it. Once this tool has been implemented, we will conduct 20 more qualitative interviews to further understand barriers and facilitators to adoption of the diagnostic tool.

The purpose of this study is to assess the extent to which engaging teachers in iterative design processes with scientists increases their content knowledge of and self-efficacy for incorporating current biomedical science into their teaching. This study includes a professional development program with a teacher-driven curriculum development component.

To test the pay-it-forward strategy as a means of increasing rates of testing for gonorrhea

We are collecting cerebral spinal fluid (CSF) from Normal Pressure Hydrocephaly (NPH) patients to generate a biosample research repository. This repository will be used to research CSF biomarkers for Alzheimer's disease that may enhance our ability to detect and monitor Alzheimer's disease diagnoses and progression.

The objectives of this pivotal clinical trial are to evaluate the safety and effectiveness of the PASCAL System for transcatheter tricuspid valve repair with OMT (optimal medical therapy) compared to OMT alone in the treatment of patients with symptomatic severe tricuspid regurgitation.

The primary objective for this registry is to prospectively study the natural history of IBD, the prevalence and incidence of comorbidities, and targeted adverse events, as well as the utilization patterns and the comparative effectiveness and comparative safety of approved IBD treatments.

Participants in this study are asked to read a list of words, then sort the words into categories based on their vowel sounds (ignoring letters). We are trying to find out how different two sounds have to be acoustically before speakers consider them to be linguistically different.

Cities are hot during daytime in summer time - much hotter than their surrounding vegetated, often forested rural areas. This effect, the Urban Heat Island Effect, is determined by building materials, human activity, and urban vegetation. But how does it affect individual thermal comfort? We are interested in understanding relationships between temperature and thermal comfort in urban areas.

Evaluate night time hemoglobin desaturation (NHD), as part of routine clinical care, in subjects with sickle cell disease (SCD

The main objective of this study is to develop methods for forecasting passenger waiting times in TSA lines at RDU airport.