This study is looking to compare the outcomes and cost of treating infected joints with surgery or aspiration with a needle combined with injection of antibiotics. Many patients with infected joints are too sick to safely go to the operating room for surgery, thus we are investigating outcomes and cost of less invasive treatment options such as using a needle to aspirate the joint and inject antibiotics.

Purpose is to evaluate the ear tube simulator and compare to actual ear tube placement in patient.

To check to see if teaching patients sign language before surgery will help with communicating after surgery when they cannot talk

To evaluate the safety and tolerability of ascending dose-levels of multiple intrathecal bolus (ITB) administrations of ION582 in patients with Angelman syndrome (AS) based on incidence and severity of treatmentemergent adverse events (TEAEs) and serious adverse events (SAEs), changes in vital signs and changes in clinical laboratory results.

The purpose of this study is to collect samples from patients with GI conditions that are coming to UNC for upper endoscopy as part of their clinical care. Samples will be stored and used for research to learn more about GI conditions.

To study the use of long-acting injectable antiretroviral therapy (LAI) among a racially, economically, and geographically diverse group of persons with HIV

The purpose of this research study is to understand how the monitoring of Patient-Reported Outcomes (PROs) could help improve surgical care for patients undergoing chest surgeries. PROs are symptoms directly reported by patients through the completion of a survey.

he purpose of Parents and Infants Inter(X)action Intervention (PIXI) is to study ways of supporting the early development of infants diagnosed with rare neurogenetic disorders in their first year of life. PIXI is funded by the John Merck Fund and is led by RTI International (RTI) in collaboration with researchers at the University of North Carolina Chapel Hill. The team includes neurodevelopmental psychologists, early interventionists, and experts in neurogenetic conditions (e.g., fragile X syndrome, Angelman syndrome), autism spectrum disorder, and early childhood development. The goal of PIXI is to provide developmental and behavioral support for infants with rare neurogenetic disorders through a two-phase targeted parent-mediated intervention program.

In Aim 1, we will use existing research and expert review to develop new text and pictorial LCC warnings and test the new warnings using online experiments to identify warnings that adult LCC users perceive as most effective. The proposed study will fill critical gaps regarding which characteristics make LCC warning labels most effective and provide needed evidence on how LCC warnings influence LCC behavioral intentions. Our overarching goal is to develop effective LCC warnings that reduce cancer and other health risks.

Examine the impact of the educational interventions on stigmatizing attitudes towards people with mental illness.