The purpose of this research study is to evaluate the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and mild neurocognitive disorder (MND) in people living with HIV (PWH). This study will also look at whether you experience any side effects from the study drugs.

This is a research study to better understand people's health behaviors.

Burnout within the health care setting is a known problem. The COVID-19 pandemic has lead to dramatic changes in the health care workplace and may lead to worsening burnout. This study aims to identify the most worrisome workplace stressors at UNC across departments so that changes can be made to address burnout.

The purpose of this study is to test the safety and effectiveness of the drug: IMVT-1402.

Immigrant teachers-who make up approximately 8% of the American K-12 teaching workforce-bring valuable diversity in terms of race, ethnicity, language, and religion. However, they also face unique challenges in addition to the systemic difficulties affecting all teachers in the U.S. education system. These challenges include navigating restrictive immigration policies, credential recognition barriers, hiring discrimination, limited career advancement, and difficulties adapting to curricula and school environments as non-native English speakers. Furthermore, they may experience racial, ethnic, and linguistic discrimination from students, parents, colleagues, and administrators, as well as structural discrimination embedded in institutional policies at the school, state, and federal levels. While there is extensive research on the discrimination faced by minoritized students and teachers of color in U.S. schools and by immigrant teachers of color in international schooling contexts, little attention has been given to the specific discriminatory experiences of immigrant teachers within the United States.

The purpose of this study is to better understand the opportunities and challenges of various kinds of gig work, paying special attention to how location and skill type impact work practices.

To develop novel PROs for evaluating QoL among patients after IPAA, including those with acute pouchitis and chronic pouch-related conditions.

To compare disease-free survival (DFS) as assessed by the investigator for high-risk renal cell carcinoma patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

Children diagnosed with Fragile X syndrome and Down syndrome are at substantially increased risk for developing neuropsychiatric disorders including autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). Despite a known genetic cause for each syndrome, substantial clinical variability exists among children with both syndromes, suggesting an important role for genetic background in shaping child outcomes. We will collect behavioral and genetic data from biological parents to model the relative role of genetic background in explaining behavioral, neurobiological, and clinical variability in young children with Fragile X and Down syndrome who have been followed with brain imaging and behavioral testing since infancy.

We are attempting to study social and political attitudes in the contemporary political context.