The purpose of this study is to determine if treating germinomas with chemotherapy followed by a lower dose of radiotherapy (RT) can be as effective as the current standard of care. Specifically, our primary aim is to determine whether 12 Gy whole ventricular irradiation (WVI) and 12 Gy tumor boost would maintain similar efficacy compared to ACNS1123 stratum 2 as measured by event-free survival (EFS) in eligible patients with localized primary central nervous system (CNS) germinoma who present with serum and/or CSF human chorionic gonadotropin-beta (hCGß) = 100 IU/L and normal AFP, and meet complete response (CR) or continued complete response (CCR) criteria following chemotherapy/second-look surgery (Stratum 1). We are attempting to build upon the excellent results of ACNS1123 stratum 2 by reducing the RT dose even further for patients in a CR after chemotherapy.

This study looks at the thoughts, beliefs, and reasons behind how gun owners in North Carolina store their guns when they have children, or have children who come to the location where their gun is stored. The results will help create gun safety programs that fit the needs of different communities.

We are studying the frequency of flooding in coastal North Carolina and the impacts of floods on households and businesses.

The purpose of this protocol addendum is to provide participants from Study LOXO-NGR-21001 (J3T-OX-JZTA), who continue to receive benefit from LOXO-260, the opportunity for continued access to LOXO-260.

This study explores the response of the adjacent gum tissue to a type of dental filling material.

We know that many children have unmet needs for care, leaving parents frustrated and discouraged. We hope, by documenting these challenges, and learning from families who have overcome them, that we can help all families.

To test an intervention for healthcare providers that combines provider education and patient resources to increase referrals to an arthritis management program

In this research study, we want to learn more about using DNA sequencing for individuals with severe mental illness. This may give clues about health risks now and in the future. You are being asked to participate in this research study because DNA sequencing may improve our understanding of schizophrenia, and what may be causing the type of illness that you have.

The purpose of this study is to examine the association of social physique anxiety and burnout, perfectionism and burnout, and the intersection of these variables together on burnout in American collegiate dancers to gain knowledge concerning burnout development in this population.

The current study seeks to understand FLE self-care practices and develop a comprehensive framework that FLEs can utilize to initiate and maintain effective self-care routines. This is particularly important given the demanding nature of their work, which involves supporting families and individuals through various life challenges and transitions