Long-term complications that may be related to chemotherapy in preparation for transplantation, bone marrow transplant, or autologous gene therapy in sickle cell patients are unknown. The purpose of this study is to answer questions about the long-term impact of having a bone marrow transplant or autologous gene therapy to treat sickle cell disease and to compare the health outcomes to individuals who have sickle cell disease but have never had a bone marrow transplant or autologous gene therapy. The study also want to compare health outcomes of those who have received a bone marrow transplant or autologous gene therapy to a healthy sibling if they had a non-related donor or autologous gene therapy. The study will also compare health to that of donor siblings.

The purpose of this study is to show that the Modified Percent Depth (MPD) (a way to calculate the severity of a pectus deformity) can be used in many different clinical settings and can reliably determine the severity of pectus excavatum.

The purpose of this research study is to collect and store blood samples from patients with heart disease at UNC-Chapel Hill for use in future research. Investigators will use these blood samples to identify new ways to measure substances made by our bodies that may help predict risk for developing heart disease or response to certain medications.

To learn about more effective ways the health care system in Zambia can care for people with non-communicable diseases (NCDs) who are also living with HIV.

The purpose of the study is to determine whether the continuing detection of cell-free plasma tumor DNA (ptDNA), circulating tumor cells (CTCs), and cytokines (chemicals that help the immune system communicate) in the blood can help to better evaluate the status of a patients cancer over the course of therapy.

To evaluate the current state of health care disparities curriculums within general surgery programs within the US.

In this survey-based study, patients with cystic fibrosis enrolled in the UNC Cystic Fibrosis Clinic will be evaluated for symptoms of Obsessive-Compulsive Disorder to determine the prevalence and severity of these symptoms in this study population.

A challenge in treating COVID-19 is early prediction of patient outcomes. Here, we develop a functional assay for patient risk stratification based on clinically observed, unique vascular signatures of COVID-19. We integrate data from this assay with patient process of care information to determine predictive metrics for risk stratification.

The purpose of this study is to better understand the everyday medical education experiences of current medical students and resident physicians and how those experiences shape their career plans.

The purpose of this research study is to better understand adolescent e-cigarette use behavior and decisions about their use. The information we learn from this research will help us develop new survey questions about e-cigarette use.