To evaluate the safety and tolerability of ascending dose-levels of multiple intrathecal bolus (ITB) administrations of ION582 in patients with Angelman syndrome (AS) based on incidence and severity of treatmentemergent adverse events (TEAEs) and serious adverse events (SAEs), changes in vital signs and changes in clinical laboratory results.

The purpose of this study is to collect samples from patients with GI conditions that are coming to UNC for upper endoscopy as part of their clinical care. Samples will be stored and used for research to learn more about GI conditions.

To study the use of long-acting injectable antiretroviral therapy (LAI) among a racially, economically, and geographically diverse group of persons with HIV

The purpose of this research study is to understand how the monitoring of Patient-Reported Outcomes (PROs) could help improve surgical care for patients undergoing chest surgeries. PROs are symptoms directly reported by patients through the completion of a survey.

he purpose of Parents and Infants Inter(X)action Intervention (PIXI) is to study ways of supporting the early development of infants diagnosed with rare neurogenetic disorders in their first year of life. PIXI is funded by the John Merck Fund and is led by RTI International (RTI) in collaboration with researchers at the University of North Carolina Chapel Hill. The team includes neurodevelopmental psychologists, early interventionists, and experts in neurogenetic conditions (e.g., fragile X syndrome, Angelman syndrome), autism spectrum disorder, and early childhood development. The goal of PIXI is to provide developmental and behavioral support for infants with rare neurogenetic disorders through a two-phase targeted parent-mediated intervention program.

In Aim 1, we will use existing research and expert review to develop new text and pictorial LCC warnings and test the new warnings using online experiments to identify warnings that adult LCC users perceive as most effective. The proposed study will fill critical gaps regarding which characteristics make LCC warning labels most effective and provide needed evidence on how LCC warnings influence LCC behavioral intentions. Our overarching goal is to develop effective LCC warnings that reduce cancer and other health risks.

Examine the impact of the educational interventions on stigmatizing attitudes towards people with mental illness.

Using online surveys to measure level of patient symptoms and seeing how regularly monitoring that impacts a patient's healthcare experience.

This study has two objectives. The first is to determine how authentic assessment is currently used in dental school curriculums. The second is to assess what potential barriers might limit the implementation of authentic assessment in more courses. Course directors will be surveyed on their use and barriers to use of authentic assessment to address these objectives.

Certain health-related undergraduate and graduate programs and courses include design thinking content and skills. We are conducting a review of syllabi and interviews with instructors of these programs or courses to better understand why and how they integrated design thinking with their health topic.