There are two main aims of this study. The first aim is to describe rates of jaw pain symptoms in patients who have root canal treatment. The second aim is to test whether a short questionnaire can identify patients with jaw pain.

This study is being done to better understand Angelman syndrome (AS). Participants will include both children and adults with a diagnosis of AS. The study will collect data regarding medical, behavioral, and developmental challenges in individuals with AS over time. Participants will be invited to return for yearly clinical evaluations yearly until the study runs out of funding. We hope clinicians will be able to help individuals with AS better if we understand the different pattern of symptoms that appear in individuals with AS over their lifetimes.

The purpose of this study is to establish that a Xenon MRI can detect brown fat and brown fat activity in greater detail in humans than a FDG-PET.

The study is designed to estimate the quality of life experienced by participants with controlled and non-controlled EoE because such estimates are useful in health economics research.

The virus that causes COVID-19 disease infects many people, but only some get sick. We want to understand how COVID affects the immune system and what makes severe COVID infections different from other diseases that cause hospitalization and breathing problems. We collect samples of blood, sputum, urine, and stool from patients in the hospital to learn how COVID affects cells and molecules of the immune system.

Hurricanes and other extreme storms often cause damage in North Carolina. This study collects data from communities and households to understand the short and long term impacts of these events and how individuals, families, and communities respond to and recover from them. The data will help us assess the full costs of extreme events and what families need in their aftermath.

Our project aims to document how COVID-19 is changing schools and families, and to trace the ways these changes are shaping educational inequality. In collaboration with North Carolina's Guilford County Schools, we are surveying school leaders, teachers, and parents and guardians about the academic, material, and socio-emotional resources that school communities are collectively employing in response to the pandemic. Our analyses will document school school/family collaboration during the COVID-19 crisis; investigate racial and socioeconomic inequalities in access to school services and supports; and evaluate the consequences of school supports and school/family collaboration for learning loses during the pandemic-induced interruption in regular schooling. Ultimately, we hope this project will shed light on strategies that can mitigate the pandemic's potentially disastrous consequences for educational inequality.

The purpose of this study is to create new ways to prevent heart disease that help people, specifically African-Americans, access resources to live a healthy life using a "whole person" approach to cardiovascular disease and social needs, especially in high-need communities.

To assess the safety of nonconforming lisocabtagene maraleucel in patients

This study will examine the efficacy of the Project ECHO model for training medical providers in western NC caring for individuals with autism.