To study the how well Pembrolizumab works on advanced tumors

The purpose of this IRB approved Humanitarian Use of a device is to allow patients to be treated with LDL-Apheresis, using the LIPOSORBER® LA-15 system. This device is approved for adult and pediatric patients with Focal Segmental Glomeruloslerosis as a Humanitarian Use Device. Its effectiveness has not been demonstrated.

The purpose of this study is to implant abnormal human parathyroid glands into mice to be used to test agents that might allow better imaging of parathyroid glands. This may improve the surgery that is sometimes required for abnormal parathyroid glands.

The purpose of this study is to follow patients who were diagnosed with HIV-1 infection during this acute infection stage to look at clinical and laboratory markers of HIV infection, over time. Individuals joining this study may or may not be on treatment for their HIV. No treatment is provided in this study. Participants may be asked to provide blood samples on this study.

The purpose for this research study is to learn more about PCD through the creation of a secure electronic clinical registry. Through this registry, researchers will be able to follow people living with PCD over time to learn more about how PCD affects people's health and the treatment people take.

To evaluate the feasibility and acceptability of a novel psychosocial intervention for parents with advanced cancer and their co-parents.

The proposed study seeks to prospectively investigate the effects of oral steroid administration following injection laryngoplasty in patients suffering from glottic insufficiency in an attempt to shorten post-procedural recovery time.

The aim of this study is to collect detailed self-reported information on HIV-infected patients' clinical, socio-demographic and behavioral characteristics to better understand who is being affected by the HIV epidemic in North Carolina and the needs of this population.

To conduct focus groups and semi-structured interviews of parents with cancer - and their co-parents - about their experiences communicating with their minor children about cancer to inform the development of a communication intervention support tool.

The purpose of this study is to evaluate both sporadic (not inherited), and familial (inherited), forms of frontotemporal lobar degeneration (FTLD). Patients include both those who have symptoms of FTLD and those who do not (yet have a family history involving FTLD). This is an observational study, meaning that there is no investigational treatment involved. We will be working with patients for up to a 5 year period to learn more about FTLD using a neurological exam, tests of memory, behavior, and judgement, MRI, and biospecimen collection (blood and/or CSF). This study involves genetic testing of the genes so far identified to be associated with FTLD. The overall goal is to help better understand FTLD, to better understand the genetics of FTLD, and to use the information we learn to guide improved patient care and potential drug development.