The main purpose of this clinical research study is to assess the safety, tolerability, efficacy (the ability of the study drug to produce the desired anti cancer effect), PK] and PD of GHF009X2101 the study drug in patients with relapsed or refractory hematologic malignancies including AML, CLL, SLL or other lymphomas [including other leukemia].

The purpose of this study is to determine the effectiveness of an 8-week yoga mindfulness meditation to identify the relationship between mindfulness yoga and stress, depression, and anxiety. Participants: Forty- four women sports student-athletes ages 18 and over in their first two years of undergraduate study at ACC member universities within a four-hour drive of the home institution. This will allow for the delivery of PAUSE-Yoga materials. Participants will complete a survey prior to the program with demographic information and the following scales: Academic Identity Measurement Scale, Athlete Identity Measurement Scale, Exercise Identity Scale, Depression, Anxiety, and Stress Scale, The International Adjustment Disorder Questionnaire, Transition Plan, Subjective Physical and Mental Health, Social Support, and Resource List. Another survey will be administered post-program with the same scales as the pre-program. Eight, 45-minute Zoom yoga sessions will be completed over 8 weeks for the PAUSE- Yoga group.

The goal of this study is to uncover the frequency of low oxygen levels during sleep in pregnant women that have severe sickle cell disease. These women have a high risk of complications during pregnancy, and low oxygen levels might contribute to the complications. Therefore, finding and treating low oxygen can be impactful. The study will also look at blood cells and assess how low oxygen affects them.

The DNA that we can test from a nasal swab, can help us determine a patient's lung cancer risk. For patients with new lung nodules found on CT scans, we are offering this nasal swab test and collecting data on how physicians use test results to help assess risk and determine treatment strategies.

Hunter Syndrome or Mucopolysaccharidosis II (MPS II) is a rare genetic disorder caused by decreased levels of a specific enzyme, iduronate-2-sulfatase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs). The build up of GAGs causes significant damage to the body and brain. This study is evaluating the use of JR-141, an enzyme replacement therapy, to provide the missing enzyme to the body. This allows for break down of the stored GAGs. JR-141 uses specific technology to cross the blood brain barrier so that the enzyme can get into the brain. JR-141 is expected to help both the cognitive (brain) and body effects of MPS II.

The purpose of the NC PASE project is to create tailored supervision guidelines (TSG) that will inform the way probation officers supervise their caseloads.

To study intellectual humility and its development across the lifespan.

Machine learning is a powerful tool for solving problems that involve a lot of data. It is being used in many different fields. The first step in creating a machine learning system is to understand what you want to achieve and then turn that goal into a plan for using machine learning. This is called problem formulation. Problem formulation is important because it not only helps you understand what you want to achieve but also helps you figure out if you have the right data to make it work. Practitioners need to try different approaches and see what works best for their data. This can take some trial and error. This study looks at a new tool designed to make problem formulation easier and see if it helps practitioners.

The Improving Provider Announcement Communication Training (IMPACT) national primary care team survey aims to investigate HPV vaccine communication among a large sample of primary care team members, including physicians, physician assistants, nurse practitioners, registered nurses and medical assistants to inform future provider communication interventions.

The purpose of this study is to measure how much methyl salicylate (MeS) is absorbed through the skin after exposure to MeS that is present in cloth.