To evaluate the safety of GBT021601 and its effect on sickle cell complications

Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades despite numerous attempts to augment standard therapies. Multi-targeted receptor tyrosine kinase inhibitors (MTKIs), such as cabozantinib, can target signaling pathways that are known to be altered in osteosarcoma. Several MTKIs including cabozantinib have recently shown clinical evidence of activity in prospective studies for both pediatric and adult patients with advanced osteosarcoma. Furthermore, feasibility of administering MTKIs in combination with cytotoxic chemotherapy has previously been shown in patients with AML, hepatocellular carcinoma, and soft tissue sarcomas. Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades

To demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection. To estimate efficacy of Bexsero in prevention of overall gonococcal infection and by anatomical site (urogenital, anorectal or pharyngeal). To assess safety of Bexsero.

Researchers from the University of North Carolina at Chapel Hill are seeking input from community members interested in joining a Community Advisory Board (CAB) with a focus on improving knowledge around the impacts of extreme weather-related disasters and healthcare access. The purpose of this CAB is to ensure the proposed research remains relevant and useful to the broader community in all phases of research - from forming partnerships to using research results to inform policy and advocacy actions.

The purpose of this study is to learn more about the experiences of families with children who have peanut or other food allergies. It also explores parents' (or other caregivers') and adolescents' perceptions of available food allergy treatments, as well as clinical research options.

The purpose of this study is to understand how different amounts of time between seeing similar word pairs affect new learning and later memory for those word pairs (e.g., knee-bone vs. knee-bend).

The purpose of this research study is to learn more about LGBTQ+/queer college students' experiences with using campus recreation facilities. The information we learn by doing this study may help us develop protocols that help campus recreation facilities provide safe and inclusive spaces for LGBTQ+/queer individuals.

To initiate and evaluate a multilevel navigation intervention to promote lung cancer screening among Black/African Americans

The purpose of this study is to identify accessibility concerns at UNC Chapel Hill and learn how physically disabled students are impacted by inaccessible spaces. Disabled students have historically faced obstacles in navigating the campus to do the same activities that able-bodies students take part in daily. By exploring the priority that the institution places on making certain buildings accessible, this study can serve as a guide for identifying further accessibility measures that must be implemented on campus.

The purpose of the study is to collect and analyze survey responses from patients who visit the outpatient diuresis clinic at UNC Eastowne in order to gain insights into their perspectives and experiences. Fiscal incentives to reduce the burden of hospital admissions have fueled interest in ambulatory strategies that can better manage heart failure, including clinic-based administration of IV diuretics. Given the clinic was started in 2017, quality improvement initiatives are necessary to continue to improve its services. This study will focus on the patient and collect qualitative data.