Mucopolysaccharidosis II (MPS II) or Hunter syndrome, is a rare genetic disorder caused by the decreased levels of a specific enzyme, iduoronate-2-sulfatase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs). The build up of GAGs causes significant damage to the body and brain. This study will evaluate the long-term use of DNL310, an enzyme replacement therapy, to provide the missing enzyme to the body and to break down the stored GAGs. DNL310 uses specific technology to cross the blood brain barrier so that the enzyme can get into the brain. DNL310 is expected to help both the cognitive (brain) and body effects of MPS II. This is an extension study to two current DNL310 clinical trials; only participants currently enrolled in these trials will have the opportunity to participate in this long-term study.

The CMR is a population based breast imaging registry for women screened for breast cancer in NC.

To assess the feasibility and acceptability of a statewide intervention to promote alternatives to incarcerations and evidence-based approaches to the treatment of pregnant and postpartum people experiencing incarceration and substance use disorder, we are conducting a virtual training for NC jail staff and will conduct pre- and post-training evaluations to assess knowledge gained about the topic.

Study of drag artists and the music they use in performance.

It is well-documented in the literature that those who have performed well on standardized tests are likely to continue to perform well. This study will interview volunteers from UNC-CH School of Medicine that are high-performing test-takers, and otherwise, in an attempt to identify qualities, characteristics, or themes shared among those who consistently perform well on tests.

Compare the ability of crowd-sourced amateurs in identifying and labeling complex constructs (here, the 4 Ps of Marketing) in user-generated content (here, Tweets) with that of generative AI (here, ChatGPT4) . Can generative AI match or even exceed crowd-sourced labels?

This study will look at the relationship between cardiovascular disease risk factors and social stress in Hispanic/Latinos with the presence of an enlarged heart or the pumping function of the heart, using echocardiography and vascular tonometry.

To determine what harm reduction services are being offered by rural pharmacies in 7 states.

In this study, listeners are asked to wear headphones or listen to sounds through a computer and make decisions about what they hear or see. We are interested in how listeners with normal hearing and hearing loss understand speech and access language.

The purpose of this study is to understand user's perspectives on VR.