Hunter Syndrome or Mucopolysaccharidosis II (MPS II) is a rare genetic disorder caused by decreased levels of a specific enzyme, iduronate-2-sulfatase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs). The build up of GAGs causes significant damage to the body and brain. This study is evaluating the use of JR-141, an enzyme replacement therapy, to provide the missing enzyme to the body. This allows for break down of the stored GAGs. JR-141 uses specific technology to cross the blood brain barrier so that the enzyme can get into the brain. JR-141 is expected to help both the cognitive (brain) and body effects of MPS II.

To understand how participation in a long-duration professional development program influenced: (a) participants' knowledge, skills, self-efficacy for teaching STEM outdoors and (b) their STEM learning ecosystems.

Machine learning is a powerful tool for solving problems that involve a lot of data. It is being used in many different fields. The first step in creating a machine learning system is to understand what you want to achieve and then turn that goal into a plan for using machine learning. This is called problem formulation. Problem formulation is important because it not only helps you understand what you want to achieve but also helps you figure out if you have the right data to make it work. Practitioners need to try different approaches and see what works best for their data. This can take some trial and error. This study looks at a new tool designed to make problem formulation easier and see if it helps practitioners.

The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced (F3) fibrosis.

We are seeking to improve knowledge around treatment of atrial fibrillation for primary care providers and patients through educational interventions.

To see if women who had breast cancer at ages 18-40 were able to successfully lactate and breastfeed after lumpectomy and radiation treatment afterwards.

A case study of ten biomedical engineering programs in which two universities collaborate on at least a Ph.D. degree. The intent is to identify circumstances that lead to successful inter-university collaboration as measured by research output, including publications and patents, along with patent citations.

The goals of this research are to: (1) understand how hearing develops throughout the lifespan; (2) determine the factors associated with successful speech, language, and hearing outcomes for individuals spanning a wide range of ages and abilities; and (3) advance auditory assessment practices for both neurotypical and diverse populations.

Purpose: To evaluate the implementation of the UNC Family Medicine behavioral health curriculum for 42 Family Medicine residents annually (98 over the course of 5 years); Participants: UNC Family Medicine residents Procedures (methods): We will analyze results of an annual survey that is administered to residents over the course of their residency 4 times: 1 at the start of their initial residency year (PGY1), 2 follow ups at the beginning of their 2nd and 3rd years of residency (PGY2 & PGY3), and 1 final at the end of their 3rd year of residency (PGY3). In addition, we will follow up with residents as able annually for 3 years after residency, 1 time per year using a post-graduation survey.

This study examines whether the use of the COMS One optical and magnetic stimulation device helps promote wound healing in diabetic foot ulcers