Hunter Syndrome or Mucopolysaccharidosis II (MPS II) is a rare genetic disorder caused by decreased levels of a specific enzyme, iduronate-2-sulfatase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs). The build up of GAGs causes significant damage to the body and brain. This study is evaluating the use of JR-141, an enzyme replacement therapy, to provide the missing enzyme to the body. This allows for break down of the stored GAGs. JR-141 uses specific technology to cross the blood brain barrier so that the enzyme can get into the brain. JR-141 is expected to help both the cognitive (brain) and body effects of MPS II.

To understand how participation in a long-duration professional development program influenced: (a) participants' knowledge, skills, self-efficacy for teaching STEM outdoors and (b) their STEM learning ecosystems.

Machine learning is a powerful tool for solving problems that involve a lot of data. It is being used in many different fields. The first step in creating a machine learning system is to understand what you want to achieve and then turn that goal into a plan for using machine learning. This is called problem formulation. Problem formulation is important because it not only helps you understand what you want to achieve but also helps you figure out if you have the right data to make it work. Practitioners need to try different approaches and see what works best for their data. This can take some trial and error. This study looks at a new tool designed to make problem formulation easier and see if it helps practitioners.

The purpose of this study is to understand user's perspectives on VR.

To determine what harm reduction services are being offered by rural pharmacies in 7 states.

People who are unable to use speech to meet their communication needs often use augmentative and alternative communication technology systems. Though many access their systems by directly touching a screen or keyboard, others with significant physical disabilities use alternate access methods. An increasingly common access method is the use of eye-tracking technologies (Fager et al., 2012), where cameras on the front of a device record where a user is looking in order to move and make selections with the on-screen mouse. This method requires users to look at the screen to move the cursor, and then to sustain their gaze on their selection for a pre-determined amount of times (i.e., dwell). The purpose of the study is to understand the impact of different types of visual feedback used to illustrate whereto cursor is on a screen on people's ability to navigate the screen with their eyes.

To evaluate the effectiveness of MED-EL Remote Care for cochlear implant users.

To conduct a discrete choice experiment (DCE) to determine what are the most important features of mobile health apps for tobacco cessation. We will conduct cognitive interviews with 10 participants to review the DCE and then fully launch the survey with 1000 participants by contracting with Qualtrics, a survey panel provider.

Demonstrate the safety and feasibility of rifaximin in the prevention of recurrent pouchitis after an initial episode of acute pouchitis.

We are interested in how people form evaluations of performance at work. Performance is an important outcome for organizations, but how we measure performance is complicated. We want to study how individuals assess other people's performance.