The purpose of this study is to optimize social media messages to encourage people to connect with others. Our goal is to create messages that resonate with populations that face a higher burden of disease.

Sanfilippo syndrome Type A or mucopolysaccharidosis type IIIA (MPS IIIA) is a rare genetic disorder caused by the deficiency of the lysosomal enzyme sulfamidase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs) in the lysosomes which leads to cellular dysfunction. The buildup of GAGs causes significant damage to the body and brain. This study is a multicenter, Phase 1/2 study to assess the safety, tolerability, and efficacy of they study drug DNL126, an enzyme replacement therapy, to provide the missing enzyme to the body. Up to 28 participants with MPS IIIA will participate in the study across multiple study sites .

The purpose of this study is to figure out the best way to work with providers and staff who treat pregnant people with very high blood pressure. We will send a nurse to 20 clinics that provide prenatal care in the community. For 12 months, the nurse will train and coach staff on implementing guidelines for addressing severe blood pressure. Some of the training will use patient actors who need their blood pressure measured, or who come to the clinic with very high blood pressure. The nurse will observe the clinic team as they interact with the "pretend" patient, and talk to them afterwards about ways to improve care. We will collect data before, during, and after the nurse has worked in the clinic. Information from 1) observations, and 2) patient charts of people who have already delivered, will tell us if our efforts in the clinics made a difference.

The purpose of this study is to compare clinical outcomes and health-related quality of life between an individualized hemodialysis prescription and conventional hemodialysis prescription in individuals requiring chronic hemodialysis who still have residual kidney function.

Compare the ability of crowd-sourced amateurs in identifying and labeling complex constructs (here, the 4 Ps of Marketing) in user-generated content (here, Tweets) with that of generative AI (here, ChatGPT4) . Can generative AI match or even exceed crowd-sourced labels?

The purpose of this study is to answer the research question: What is the best protocol for a barium swallow including patient positioning, methods, and contrast administration?

The purpose of this study is to develop messages about the harms of using tobacco products.

As the most visited national park in the United States, Great Smoky Mountains National Park (GRSM) has experienced social and environmental consequences due to overcrowding. This study will identify visitors' motivations behind park stewardship to inform communications recommendations to the national park.

The purpose of this study is to determine the safety of the addition of universal donor, expanded NK cells to gemcitabine/docetaxel for treatment of relapsed and refractory sarcomas.

To evaluate safety and efficacy of therapeutic vaccination with chimpanzee adenovirus (ChAdV)- and poxvirus modified vaccinia Ankara (MVA)-vectored vaccines in a sequential regimen with the Toll-like Receptor 7 (TLR7) agonist vesatolimod (VES) and two broadly neutralizing antibodies (bNAbs) in individuals with HIV-1 who started suppressive antiretroviral therapy (ART) during acute HIV-1.