Hunter Syndrome or Mucopolysaccharidosis II (MPS II) is a rare genetic disorder caused by decreased levels of a specific enzyme, iduronate-2-sulfatase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs). The build up of GAGs causes significant damage to the body and brain. This study is evaluating the use of JR-141, an enzyme replacement therapy, to provide the missing enzyme to the body. This allows for break down of the stored GAGs. JR-141 uses specific technology to cross the blood brain barrier so that the enzyme can get into the brain. JR-141 is expected to help both the cognitive (brain) and body effects of MPS II.

To understand how participation in a long-duration professional development program influenced: (a) participants' knowledge, skills, self-efficacy for teaching STEM outdoors and (b) their STEM learning ecosystems.

Machine learning is a powerful tool for solving problems that involve a lot of data. It is being used in many different fields. The first step in creating a machine learning system is to understand what you want to achieve and then turn that goal into a plan for using machine learning. This is called problem formulation. Problem formulation is important because it not only helps you understand what you want to achieve but also helps you figure out if you have the right data to make it work. Practitioners need to try different approaches and see what works best for their data. This can take some trial and error. This study looks at a new tool designed to make problem formulation easier and see if it helps practitioners.

The purpose of this study is to measure how much methyl salicylate (MeS) is absorbed through the skin after exposure to MeS that is present in cloth.

We are seeking to improve knowledge around treatment of atrial fibrillation for primary care providers and patients through educational interventions.

To further understand the perspectives and health literacy of parents of children with chronic medical conditions before their child transitions from pediatric to adult care

This is a research study to learn about the mental health of people living with HIV in the Democratic Republic of Congo. Participants will answer one survey that will take approximately 15 minutes to complete.

The United States is facing a worsening physician shortage that particularly affects people living in rural or underserved communities. One strategy used to address this problem is clinical exposure programs for students in high school, college, and/or medical school. Research currently suggests that these programs could influence participants' interest in medicine, specialty choice, and practice location preferences. Mentoring in Medicine is a summer clinical exposure program that targets college students in the Johnstown area of Pennsylvania. This region of the state is socioeconomically disadvantaged and medically underserved. No formal follow-up has been conducted on the participants since the program began in 2004. We plan on surveying these past participants to examine their academic and career interests and outcomes. We will also use physician databases to determine career outcomes. This data will help contribute to the body of evidence regarding educational interventions to improve medical shortages in the United States.

The purpose of the study is to gain a better understanding of Black women's experiences with communication, relationships, and interactions with their women's health care providers. Specifically, we are interested in 1) exploring Black women's experience of racism or discrimination and stress, 2) understanding the importance of racial concordance between Black women and their obstetric care providers, and 3) describing Black women's lived experiences with their obstetric care providers.

To see if women who had breast cancer at ages 18-40 were able to successfully lactate and breastfeed after lumpectomy and radiation treatment afterwards.