The purpose of the HEALEY ALS Platform Trial is to develop and administer various clinical trials under different regimens with ALS to provide multiple treatment options for patients with ALS.

Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades despite numerous attempts to augment standard therapies. Multi-targeted receptor tyrosine kinase inhibitors (MTKIs), such as cabozantinib, can target signaling pathways that are known to be altered in osteosarcoma. Several MTKIs including cabozantinib have recently shown clinical evidence of activity in prospective studies for both pediatric and adult patients with advanced osteosarcoma. Furthermore, feasibility of administering MTKIs in combination with cytotoxic chemotherapy has previously been shown in patients with AML, hepatocellular carcinoma, and soft tissue sarcomas. Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades

Researchers from the University of North Carolina at Chapel Hill are seeking input from community members interested in joining a Community Advisory Board (CAB) with a focus on improving knowledge around the impacts of extreme weather-related disasters and healthcare access. The purpose of this CAB is to ensure the proposed research remains relevant and useful to the broader community in all phases of research - from forming partnerships to using research results to inform policy and advocacy actions.

The purpose of this study is to learn more about the experiences of families with children who have peanut or other food allergies. It also explores parents' (or other caregivers') and adolescents' perceptions of available food allergy treatments, as well as clinical research options.

The purpose of this study is to assess the effect of emotional support groups and educational webinars on the well-being of patients with rare dermatologic conditions characterized by blistering. Patients will be given a survey before and after participating in six support group and webinar meetings.

To initiate and evaluate a multilevel navigation intervention to promote lung cancer screening among Black/African Americans

To improve adolescent health by leveraging teachers to provide mental health care for adolescents with poor access to care in Darjeeling, India

The study is designed to provide information, resources, and support to journalists in the study as they cover the 2023 North Carolina municipal elections and assess effectiveness of those resources.

This study will compare 3 different ways to educate patients with advanced chronic kidney disease about hemodialysis vascular access.

The purpose of this study is to develop a strategy that increases the readiness of high school coaches to implement ACL injury prevention programs with their teams.