To compare the prevalence, severity, and timing of chronic health conditions (CHC) in a cohort of patients with DS-AL (Down Syndrome Acute Leukemia) with age-comparable DS individuals that have no cancer history. Our secondary objectives will compare NP (Neuro-Psychological) and health-related quality of life outcomes in survivors of DS-AL compared with age-comparable DS individuals with no cancer history, and will identify risk determinants of CHC and NP late effects among survivors of DS-AL.

The purpose of this study is to determine if treating germinomas with chemotherapy followed by a lower dose of radiotherapy (RT) can be as effective as the current standard of care. Specifically, our primary aim is to determine whether 12 Gy whole ventricular irradiation (WVI) and 12 Gy tumor boost would maintain similar efficacy compared to ACNS1123 stratum 2 as measured by event-free survival (EFS) in eligible patients with localized primary central nervous system (CNS) germinoma who present with serum and/or CSF human chorionic gonadotropin-beta (hCGß) = 100 IU/L and normal AFP, and meet complete response (CR) or continued complete response (CCR) criteria following chemotherapy/second-look surgery (Stratum 1). We are attempting to build upon the excellent results of ACNS1123 stratum 2 by reducing the RT dose even further for patients in a CR after chemotherapy.

This study will collect information from colorectal surgeons throughout the United States with regard to their access to pelvic exenteration surgery for their patients with rectal cancer. We will assess their personal comfort with performing the procedure as well as their perceived access to colleagues who can provide the procedure. We will also assess educational and support needs amongst colorectal surgeons with regard to pelvic exenteration.

The purpose of this study is to improve the treatment of children and young adults with all stages of FHWT, so that more patients are cured without relapse, and that side effects from treatment are lessened without decreasing cure rates. This study will use information on higher or lower risk features of FHWT to adjust the treatment of each subject based on their risk of relapse.

The purpose of this study is to assess how the use of community health-workers for human papillomavirus (HPV) testing influences the number of women living with HIV who get screened for cervical cancer.

The purpose of this research is to see if a radioactive tracer called (21-[18F]fluoro-16α,17α-[(R)-1'-α- furylmethylidene)dioxyl]-19-norpregn-4-ene-3,20 dione) (also referred to as 18F-FFNP) with positron emission tomography (PET) scanning can provide more information about your response to endocrine therapy when it is combined with Abemaciclib, a member of the class of medications known as CDK4/CDK6 inhibitors.

The purpose of this study is to learn what women with HIV think about cervical cancer screening. We also want to talk about the idea of using HPV self-collection (where women collect their own sample) instead of going to the clinic for testing. This information will help us see if self- collection can help more women with HIV get screened for cervical cancer.

The aim of this study for low and standard risk germ cell tumor (GCT) patients is to minimize toxicity by reducing therapy while maintaining current survival rates. The trial will eliminate chemotherapy for low risk patients who are likely cured with surgery and will observe the salvage rates among those who recur.

To provide AMTAGVI per United States Prescribing Information (USPI) to patients.

Using online surveys to measure level of patient symptoms and seeing how regularly monitoring that impacts a patient's healthcare experience.