The purpose of this single-arm phase 2 study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients.

We want to learn more about how patients who have small renal masses make treatment decision and about what kinds of features they value in the tests that we use to work up this condition.

Ovarian cancer is the second most frequently diagnosed gynecologic cancer in the United States. Although it is the eleventh most common cancer among women, ovarian cancer is the fifth leading cause of cancer-related death. Fortunately, survival rates for ovarian cancer patients have been improving over the past few decades due to advances in medical procedures and the availability of new cancer drugs. However, studies have shown that the improvement of clinical outcomes are unequal among patients of different racial and ethnic backgrounds. This study seeks to understand the factors associated with healthcare disparities in Black ovarian cancer patients and identify features of programs that have been successful in addressing these racial imbalances. The findings of this study will help the researcher develop future programs to address healthcare disparities in Black ovarian cancer patients.

The goal of this study is to see if it is feasible to use electronic questionnaires to measure patient related outcomes before, during, and after radiation for gynecologic cancer in a high-volume radiation oncology clinic.

This is a non-interventional, observational study to collect data on survival, quality of life, and other follow-up information on patients who receive GammaTile therapy.

We aim to characterize work exposures and illness in Badin, North Carolina--the site of an aluminum smelting facility for nearly 100 years.

To comprehensively characterize the clinical, laboratory, and histopathologic features of breast cancer patients receiving care according to local standards in Malawi.

The purpose of this research study is to learn more about Barrett's Esophagus and esophageal cancer by collecting data and samples (blood and tissue) for a biorepository. A biorepository is a large bank of specimens and data that are stored indefinitely and may be shared with other researchers.

The purpose of this study is to assess how the use of community health-workers for human papillomavirus (HPV) testing influences the number of women living with HIV who get screened for cervical cancer.

This partially randomized phase II/III trial studies how well cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or liver cancer after surgery. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving combination chemotherapy after surgery may kill more tumor cells.