Patients will undergo a blood draw for a gene classifier test. Some patients will have their physicians informed of the result, and another group of patients will be randomized to be managed by standard of care. Qualifying patients have incidentally identified lung nodules assessed as < 50% risk of cancer.

The main goal of this project is to create an interactive online version of the Let's Talk program and test it with patients who have Lynch syndrome to see if it works well in a medical setting.

This is a research study to compare quality of life (QOL) and physical function impairment among breast cancer and lymphoma survivors in Malawi to age- and sex-matched controls, using the PROMIS survey and objective performance-based measures.

The purpose of this study is to determine if treating germinomas with chemotherapy followed by a lower dose of radiotherapy (RT) can be as effective as the current standard of care. Specifically, our primary aim is to determine whether 12 Gy whole ventricular irradiation (WVI) and 12 Gy tumor boost would maintain similar efficacy compared to ACNS1123 stratum 2 as measured by event-free survival (EFS) in eligible patients with localized primary central nervous system (CNS) germinoma who present with serum and/or CSF human chorionic gonadotropin-beta (hCGß) = 100 IU/L and normal AFP, and meet complete response (CR) or continued complete response (CCR) criteria following chemotherapy/second-look surgery (Stratum 1). We are attempting to build upon the excellent results of ACNS1123 stratum 2 by reducing the RT dose even further for patients in a CR after chemotherapy.

This study will collect information from colorectal surgeons throughout the United States with regard to their access to pelvic exenteration surgery for their patients with rectal cancer. We will assess their personal comfort with performing the procedure as well as their perceived access to colleagues who can provide the procedure. We will also assess educational and support needs amongst colorectal surgeons with regard to pelvic exenteration.

Purpose: to establish a Registry of pediatric patients treated with proton radiation therapy. Participants: Patients who are less than or equal to 21 years old at time of treatment start and treated with radiation therapy at one of the participating centers. Procedures (methods): This Proton and Photon Consortium Registry (PPCR) enrolls children treated with radiation therapy to form an expansive description of the pediatric population that receives protons and to better catalogue the benefits of protons, in this cohort. The data will also be used to evaluate practice differences and help facilitate collaborative research across the various radiation centers. The PPCR collects an expanded set of demographic and clinical data that will enhance the practice data that many participating radiation centers already collect in their routine operations. The PPCR has been expanded to include a photon-treated control group, helping to facilitate comparative effectiveness analysis.

To compare the prevalence, severity, and timing of chronic health conditions (CHC) in a cohort of patients with DS-AL (Down Syndrome Acute Leukemia) with age-comparable DS individuals that have no cancer history. Our secondary objectives will compare NP (Neuro-Psychological) and health-related quality of life outcomes in survivors of DS-AL compared with age-comparable DS individuals with no cancer history, and will identify risk determinants of CHC and NP late effects among survivors of DS-AL.

We are surveying families of pediatric hematology/oncology patients to find out their interest in and use of integrative and complementary health practices.

We are conducting this study to better understand the relationship between access to care, financial stress and health related quality of life among cancer patients in NC who live in rural areas. We will be interviewing 30 rural cancer patients to learn about their cancer experience and we will be reviewing previously completed surveys about their distress and coping behaviors.

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.