The purpose of this study is to test the safety of the two study drugs, venetoclax and selinexor, and to find the highest dose of venetoclax and selinexor that can be given safely when it is combined with chemotherapy drugs (cytarabine or cytarabine and fludarabine). This study tests different doses of venetoclax and selinexor to see which dose is safer in children with leukemia.

Research with blood and cells (generally called specimens) can help researchers understand how the human body works. Research can also answer other questions by using specimens. Researchers may develop new tests to find diseases, or new ways to treat diseases. In the future, research may help to develop new products, such as drugs. You are being asked for permission to use your biospecimens and medical records for this study. Using your biospecimens, researchers may be able to detect CAR-T cells in your body after you receive the CAR-T treatment. The purpose of this study is to validate the detection method of CAR-T cells in the blood to advance CAR-T therapy development.

The purpose of this study is to create an educational video on colorectal cancer, screening and prevention, and clinical trials in Spanish in order to demonstrate a correlation between increased education and increased willingness to participate in clinical trials in the Latinx populations through local churches.

Purpose: To develop, assess, and refine a brief electronic patient-reported outcome (ePRO) tool that can be completed weekly by patients with newly diagnosed breast and colorectal cancer to self-report progress from diagnosis to treatment initiation.

The purpose of this project is to identify and target barriers faced by rural endometrial cancer patients in order to develop a patient navigation intervention. Rural residents with endometrial cancer, the most prevalent gynecologic cancer in the US, have higher odds of mortality than urban endometrial cancer patients. As the number of new endometrial cancer cases is expected to increase 50% by 2030, this urban-rural disparity is expected to continue widening.

The purpose of this project is to identify and target barriers faced by rural endometrial cancer patients in order to develop a patient navigation intervention. Rural residents with endometrial cancer, the the most prevalent gynecologic cancer in the US, have higher odds of mortality than urban endometrial cancer patients. As the number of new endometrial cancer cases is expected to increase 50% by 2030, this urban-rural disparity is expected to continue widening.

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

Collecting data on chronic GVHD instances

The purpose of this study is to evaluate the efficacy of sodium thiosulfate (STS) infusion administered during cisplatin-containing chemotherapy cycles in reducing hearing loss in children with newly-diagnosed average-risk medulloblastoma.

The DNA that we can test from a nasal swab, can help us determine a patient's lung cancer risk. For patients with new lung nodules found on CT scans, we are offering this nasal swab test and collecting data on how physicians use test results to help assess risk and determine treatment strategies.