The purpose of this research study is to deliver 6 months of 1:1 health coaching to cancer patients being treated at UNC Cancer Hospital. This program hopes to improve patient's self-confidence and satisfaction with how they feel and what they are able to do day-to-day. This includes exercising, support for healthy eating, emotional and social needs. Health coaching means you will receive weekly phone calls and emails from a trained coach.

Have you been diagnosed with Acute Lymphoblastic Leukemia? Has your leukemia come back or didn't get better after your last treatment? If so, you may be able to take part in a research study to learn more about the safety of modifying your own immune cells to treat your leukemia.

The purpose of this study is to understand how your gut plays a role in how well CAR T cell therapy works. Your gut is home to bacteria, which we call the gut microbiome. The gut microbiome can send signals to your immune cells, which may impact how well and how long CAR T cell therapy will last. We can find out what type of bacteria are in your gut microbiome by studying your stool. We can understand more about the signals sent to the immune system by studying your blood. We will ask for stool and blood at the same time points throughout your treatment. We will study the identities and function of the bacteria and immune cells to understand more about how these signals work during CAR T cell treatment.

Participants in this study will be asked to give a small blood sample during a routine clinic check-up. Researchers will be looking at blood components and compare with expected venetoclax concentrations. The overall goal is to be able to use specific blood components ("biomarkers") to better optimize venetoclax doses for CLL patients.

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. This protocol will allow access to cord blood units that are unlicensed.

we will be conducting 60-minute interviews with young adults to hear about social connections (in person and online) and cancer support on social media

To conduct focus groups and semi-structured interviews of parents with cancer - and their co-parents - about their experiences communicating with their minor children about cancer to inform the development of a communication intervention support tool.

To compare the prevalence, severity, and timing of chronic health conditions (CHC) in a cohort of patients with DS-AL (Down Syndrome Acute Leukemia) with age-comparable DS individuals that have no cancer history. Our secondary objectives will compare NP (Neuro-Psychological) and health-related quality of life outcomes in survivors of DS-AL compared with age-comparable DS individuals with no cancer history, and will identify risk determinants of CHC and NP late effects among survivors of DS-AL.

Screening tool to collect broader demographic and clinical data. Enhance understanding of site specific and trial specific accrual barriers.

The purpose of this study is to collect evidence for or against the addition of olanzapine to standard nausea/vomiting prophylaxis in children receiving cyclophosphamide-based Bone Marrow Transplant conditioning. Its findings will be generalizable to children receiving other types of chemotherapy that have the potential to increase nausea/vomiting.