People with kidney disease that have the APOL1 risk variant are at a greater risk for developing protein in their urine and chronic kidney disease. This research study is being done to determine if the investigational drug, VX-147 can slow or stop the worsening of kidney function as well as target the underlying cause of kidney disease.

In this study, we want to learn more about health behaviors and access to health information from families with children under six.

Have you or your child been diagnosed with type 1 diabetes during the past 12 months? Are you interested in helping researchers learn more about how to delay or prevent type 1 diabetes or how to treat type 1 diabetes? Join a registry to be notified of future opportunities to participate in type 1 diabetes research!

The purpose of this study is to compare the bacteria in women who are taking either methenamine hippurate (Hiprex) or nitrofurantoin (Macrobid, Macrodantin) every day to prevent urinary tract infections (UTIs). We will compare bacteria in the bladder, vagina, and rectum. The information we learn by doing this study may help us better understand how these medications work to prevent UTIs.

In this study, we want to hear from patients with metastatic breast cancer about how their oncologists speak with them about their prognosis. We know these conversations can be challenging, and we want to hear from patients and caregivers about what is helpful or not helpful in those conversations. We also want to hear from patients about a breast cancer-specific tool.

We now know there is a link between sedentary behavior (e.g., sitting) and heart disease. However, we do not yet fully understand if sedentary behavior performed in different settings and situations (e.g., sitting alone watching television vs sitting with friends at a bar) differentially impacts heart disease risk. This is what this study aims to find out.

The purpose of this study is to assess if a filmed dramatized story intervention (telenovela/soap opera) called Infección de Amor (Love Infection), a culturally tailored and technology delivered intervention for Latinas in the United States (US) can help Latinas prevent HIV infection. Participants will be Latinas ages 18-44 years who report sexual activity with a man in the last 6 months, have internet access from any device, and reside in NC.

Many young athletes who tear their ACL have trouble getting back to sport or suffer a second ACL injury once they do. We aim to improve athletes' ability to get back to sport safely. We want to make the activities athletes perform in rehabilitation more closely match the demands of what they do once they return to their sport. We also aim to develop low-cost ways to measure how the knee is moving during those activities. *This study is a collaboration with the UNC Sports Medicine Institute*

The purpose of this study is to investigate the reliability of multiple body composition techniques in a multi-ethnic population.

Are you pregnant? Are you high risk? We know it is stressful to be pregnant when you are high-risk. We are trying to learn more about how different aspects of your life - including activity, diet, environment, stress level, and social support affect pregnancy outcomes. Compensation provided.