To test the safety and efficacy of a new treatment for hypothalamic obesity.

The aim of the current study is to evaluate the effects of ziltivekimab on heart failure symptoms and physical function in participants with mildly reduced or preserved heart function and evidence of inflammation.

To test if study drug can help improve well being of patients with heart failure

Recent updates to the clinical practice guidelines of the American Heart Association (AHA) and US Preventive Services Task Force (USPSTF), now recommend against the use of aspirin for primary prevention in older adults due to the associated bleeding risks​. Moreover, it is estimated that 25-40% of older adults continue routine aspirin consumption without evidence-based clinical indications​. Using the emergency department as a platform to evaluate patients' perspectives on discontinuing aspirin in scenarios where the risks or potential drawbacks surpass the benefits. This assessment takes into account the patient's care objectives, existing functionality, life expectancy, values, and preferences.

The University of North Carolina Age-Based Genomic Screening program is an innovative paradigm that aims to provide targeted and highly actionable genetic information to parents via their child's routine wellness visits. The final stage of the program involves a pilot study that will expand pediatric genetic screening in well-child care across the states. In preparation for this final stage, we will conduct interviews with parents or caregiver of children in North Carolina to inform an implementation plan, educational and training materials, and evaluation plan for the pilot study. The interviews will consist of questions aimed at assessing barriers and facilitators to the implementation of ABGS, including parents' and children's healthcare and genetic screening experiences (such as blood and saliva collection), perceptions and interest in the ABGS program, expectations and experiences with healthcare providers, and the information needed for participation decisions.

This study focuses on how communities near the coast deal with frequent but shallow flooding. We focus on small towns in Carteret County, NC, where families have lived for a long time. We want to talk to residents here to understand how they see their quality of life changing as flooding increases. We also want to see if their tolerance for this type of flooding changes depending on how bad it is and which areas are affected. By talking to residents and modeling flooding, we hope to characterize how livable this place may be in the future considering these floods.

The purpose of this study is to find out if an online learning module can be just as effective as in-person training for teaching anesthesia residents how to use a defibrillator. A defibrillator is a machine that helps restart a person's heart when it stops beating. The study will look at how well the residents can perform important tasks, like using the defibrillator to deliver a shock to the heart, both right after they learn and four months later. The goal is to see if the online training works as well as traditional hands-on training and if the residents prefer one method over the other.

The purpose of the study is two-fold. The first is to conduct an adaptation of a microeconomic strengthening and stigma reduction intervention for young people with HIV in Zambia. The second is to pilot test the adapted intervention and assess its feasibility, acceptability, implementation costs, and preliminary effects.

The purpose of this study is to gather information from local public health departments in Texas on efforts to link individuals in their community to social and/or medical services also referred to as care coordination. The researchers seek to understand how care coordination work may help strengthen local public health departments.

A multi-center open-label trial evaluating the efficacy and safety of daratumumab in treatment of patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposits.