The purpose of this research study is to evaluate changes in liver protein function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to healthy volunteers and non-ADPKD patients with kidney disease. ADPKD is a common genetic disease where fluid-filled cysts develop and grow in both kidneys, leading to kidney failure. It affects about 1 out of every 1000 people worldwide. In some patients, the cysts also develop in the liver, causing some degree of liver impairment, which can have various ill consequences. There are many ways that the liver cysts could cause liver problems. Our study will test if the molecules (e.g. bile acids, coproporphyrins) in your blood and urine will be increased/decreased and if certain genes are different in different populations (i.e. healthy people vs patients). This will be determined from blood and collecting urine. Finally, scientists on our team will run analyses to detect the differences.
Thank you for your interest, but this study is not currently enrolling.
North Carolina (Statewide)
UNC Eshelman School of Pharmacy-Division of Pharmacotherapy and Experimental Therapeutics
Clinical or Medical
Genetics and Genetic Disorders
Healthy Volunteer or General Population
Kidneys and Liver
Urinary and Bladder