• Home
  • Study Details
Not currently enrolling

Serum and Urine Endogenous Compound Profiling in Autosomal Dominant Polycystic Kidney Disease

The purpose of this research study is to evaluate changes in liver protein function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to healthy volunteers and non-ADPKD patients with kidney disease. ADPKD is a common genetic disease where fluid-filled cysts develop and grow in both kidneys, leading to kidney failure. It affects about 1 out of every 1000 people worldwide. In some patients, the cysts also develop in the liver, causing some degree of liver impairment, which can have various ill consequences. There are many ways that the liver cysts could cause liver problems. Our study will test if the molecules (e.g. bile acids, coproporphyrins) in your blood and urine will be increased/decreased and if certain genes are different in different populations (i.e. healthy people vs patients). This will be determined from blood and collecting urine. Finally, scientists on our team will run analyses to detect the differences.

Age & Gender

  • 40 years ~ 70 years
  • Male, Female

Contact the Team


Thank you for your interest, but this study is not currently enrolling.

North Carolina (Statewide)

Additional Study Information

Principal Investigator

Vimal Derebail
UNC Eshelman School of Pharmacy-Division of Pharmacotherapy and Experimental Therapeutics

Study Type

Clinical or Medical

Study Topics

Genetics and Genetic Disorders
Healthy Volunteer or General Population
Kidneys and Liver
Urinary and Bladder

IRB Number


logo for the North Carolina Translational and Clinical Sciences Institute
logo for UNC Health
logo for UNC School of Medicine
logo for UNC Research
Research for Me logo

Copyright © 2013-2020 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH.  This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.


  • This email address is being protected from spambots. You need JavaScript enabled to view it.