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Not currently enrolling

MEtformin and Lorcaserin for WeighT Loss in Schizophrenia (MELT)

The purpose of this study is to test new pharmacologic strategies for weight loss in patients with schizophrenia, a population for which no current weight-loss treatments have gained widespread use. The goal is to recruit overweight people with schizophrenia to participate in a 52-week double-blind, randomized study to assess the efficacy and safety of lorcaserin/metformin combination treatment, lorcaserin monotherapy, and placebo on weight, body composition, and measures of glucose and lipid metabolism.

Age & Gender

  • 18 years ~ 65 years
  • Male, Female

Contact the Team


Thank you for your interest, but this study is not currently enrolling.

North Carolina (Statewide)

Additional Study Information

Principal Investigator

Fred Jarskog
Psychiatry - NC Research Center

Study Topics

Eating, Nutrition, and Metabolism
Mental and Emotional Health

IRB Number


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