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XTRA Study

We are learning about the safety of combining a cell therapy (HXTC therapy) with regular doses of a drug called Vorinostat (VOR) as a possible approach for improving the strength of your immune system against HIV. In this study, we will collect your blood, remove the cells in your immune system that fight infection (T cells), and expose them to HIV proteins so that they will recognize the HIV virus again. These re-educated T cells are called HXTCs (HIV-specific T cells). In this study we will use HXTC therapy (putting your re-educated T cells back into your body to get your immune system to respond better against HIV) along with the drug VOR, which has been shown to stimulate your resting CD4 cells to become active and release the HIV virus.

Age & Gender

  • 18 years ~ 64 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Visits can be combined with regular clinical appointments


North Carolina (Statewide)

What will be asked of you

Clinic visits with 2 blood procedures


up to $3350 for completion of all study visits and procedures, Travel reimbursement may be available for participants who travel more than 50 miles one-way to the study visits.

In-person visits : 24
Total length of participation : up to 13 months (1 year and 1 month)

Looking for Specific Volunteers

Able to participate:

  • Male and female people living with HIV
  • On antiretroviral therapy (ART) and suppressed for at least 2 years
  • CD4 count greater than 350 cells/mm3
  • Have ability to have a driver present to transport home after some visits
  • Able and willing to continue ART throughout the study

Not eligible if:

  • Problems with having your blood drawn
  • You have a known cardiovascular risk
  • Active syphilis, Hepatitis B or C infection
  • You are pregnant or breastfeeding or planning to get pregnant or father a child
  • You are receiving chemotherapy or radiation therapy for any active cancer

Contact the Team

Visit Location

100% Remote (online, phone, text)

Additional Study Information

Principal Investigator

David Margolis
Medicine-Infectious Diseases

Study Type

Clinical or Medical

Study Topics


IRB Number




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