• Home
  • Study Details

Treatments for Vaginal Pain (Vestibulodynia): The UPDATe Study

This is a research study about vestibulodynia, a condition where women feel pain at the opening of the vagina. They feel this pain regularly when there is pressure in the vagina from using tampons and/or pressure from sexual activity. Vestibulodynia is very common - it affects one out of every six women of reproductive age. Through this study, we hope to find out which medications work best to relieve pain from vestibulodynia, and also find out more about what is happening in the body when women experience this pain.

Age & Gender

  • 18 years ~ 50 years
  • Female

Visit Availability

  • Standard business hours (M-F, 8-5)


North Carolina (Orange)

What will be asked of you

If you express interest in the study, the next step is a 10-15 minute pre-screening phone call to see if you qualify and to share information about the study with you. This phone call may be completed by email instead of phone if you prefer. Participants will attend four in-person visits at UNC Hospitals, Hillsborough campus over six months. Each visit is 2-3 hours long and includes questionnaires, blood tests, physical exam and medication dispensed to take at home.


$60 Visa gift card upon completion of all study visits. Contact study team for more details.

In-person visits : 4
Phone or online visits : 1
Total length of participation : six months

Looking for Specific Volunteers

Able to participate:

  • At least 3 continuous months of pain with sexual activity involving penetration into the vagina,
  • or pain with touch to the vaginal opening,
  • or pain with tampon insertion.

Not eligible if:

  • Pregnant, breastfeeding or planning to become pregnant during the six month study period. We will review other exclusion criteria during the pre-screening phone call or email.

Contact the Team

Visit Location

100% Remote (online, phone, text)

Additional Study Information

Principal Investigator

Elizabeth Geller
Obstetrics and Gynecology-Urogynecology and Reconstructive Pelvic Surgery

Study Type

Clinical or Medical

Study Topics

Women's Health

IRB Number




logo for the North Carolina Translational and Clinical Sciences Institute
logo for UNC Health
logo for UNC School of Medicine
logo for UNC Research
Research for Me logo

Copyright © 2013-2020 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH.  This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.


  • This email address is being protected from spambots. You need JavaScript enabled to view it.