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Changes Study

The purpose of our study is to understand the role of estrogen fluctuation in combination with stressful life events in altering the normal biological responses to stress and, in so doing, triggering depression and anxiety symptoms. We also seek to examine whether stabilizing the estrogen fluctuation will have a beneficial effect on the biological responses to stress and mood symptoms.

Age & Gender

  • 45 years ~ 60 years
  • Female

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)
  • In-home visits available

Location

North Carolina (Statewide)

What will be asked of you

1 enrollment, 1 gynecological exam, 5 lab sessions, 14 blood draws. 1 phone screen

Incentives

up to $1,275

In-person visits : 22
Phone or online visits : 1
Total length of participation : 24-28 weeks

Looking for Healthy Volunteers

Requirements for healthy volunteers are different than for those with a specific condition. If you are interested in becoming a healthy volunteer for this study, use the below categories to determine if you are able to participate.

Able to participate:

  • In generally good health
  • In the menopause transition (having irregular or skipped periods)
  • Currently experiencing symptoms of depression and anxiety

Not eligible if:

  • Current use of psychotropic medications, hormonal preparations, or certain herbal supplements (e.g. St. John's Wort or black cohosh)
  • Currently suffer from, or have a history of: any cardiovascular disease, diabetes, cancer, bipolar disorder, or psychosis
  • Strong family history of breast, ovarian, or uterine cancer
  • BMI >37

Contact the Team

Visit Location

100% Remote (online, phone, text)

Additional Study Information

Principal Investigator

Susan Girdler
Psychiatry - Research

Study Type

Clinical or Medical
Interventional

Study Topics

Healthy Volunteer or General Population
Mental and Emotional Health
Women's Health

IRB Number

16-1731

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