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Prospective Investigation of Biomarkers in HPV+ Oropharyngeal Squamous Cell Carcinoma

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Location

North Carolina

What will be asked of you

The study involves collecting tumor and blood samples, and quality of life assessments.

Total length of participation:
5 years

Looking for Specific Volunteers

Able to participate:

  • Medically diagnosed with oropharyngeal cancer
  • Tumor must be caused by the human papillomavirus (HPV
  • Must plan for curative (healing) therapy
  • No prior therapy for this tumor

Not eligible if:

  • Evidence of disease progression
  • Transplant patient on chronic immunosuppression
  • Prior history of radiation therapy to the head and neck cancer

Contact the Team

Visit Location

  •  Lineberger Clinical Research

100% Remote (online, phone, text)

Additional Study Information

Principal Investigator

Wendell Yarbrough
Radiation Oncology - Chapel Hill

Study Type

Clinical or Medical
Observational

Study Topics

Cancer (Head and Neck)

IRB Number

20-2065

ClinicalTrials.gov

NCT04564989

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Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH.  This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

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