The purpose of this study is to compare the effectiveness of the drug megestrol alone, or combined with metformin, on the growth of Endometrial Intraepithelial Neoplasia.
This study aims to treat your cancer and closely resembles routine care that would be received regardless of participating on a research study. To participate on the study, you will frequently meet with a member of the study team in addition to your oncology care team. The study involves physical exams; blood tests, study biopsy; specimen collection; questionnaires:( tobacco and alcohol use;COVID-19 exposure and vaccination status); use of study diary. This study is composed of 2 groups; a computer will assign you to one of the 2 groups. group 1: if you are in this group, you will receive megestrol acetate pills by mouth twice a day for 3 to 5 weeks ; group 2: if you are in this group, you will receive megestrol acetate and metformin pills twice a day by mouth for 3 to 5 weeks. Your doctor will continue to follow your condition for up to 42 days
$50 after completion of each study visit, to reimburse you for your time, transportation, parking, and other expenses related to the study
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA
Leslie Clark
LCCC - Clinical Trials
Clinical or Medical
Interventional
Cancer (Uterine (endometrial))
21-1109